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World J Stem Cells. Jan 26, 2021; 13(1): 64-77
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.64
Pancreatic β cell regeneration induced by clinical and preclinical agents
Kang-Li Wang, Ming Tao, Tian-Jiao Wei, Rui Wei
Kang-Li Wang, Tian-Jiao Wei, Rui Wei, Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing 100191, China
Ming Tao, Department of General Surgery, Peking University Third Hospital, Beijing 100191, China
Author contributions: Wang KL and Tao M contributed equally to this work; Wang KL, Tao M, and Wei TJ collected the supportive literature and drafted the manuscript; Wei R conceived the manuscript, reviewed the literature, and revised and proofread the manuscript; all authors have read and approved the final manuscript.
Supported by the National Key Research and Development Program of China, No. 2016YFA0100501; the National Natural Science Foundation of China, No. 81770768 and No. 81970671; and the Natural Science Foundation of Beijing, No. 7192225.
Conflict-of-interest statement: The author declares no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui Wei, MD, PhD, Department of Endocrinology and Metabolism, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. weirui@bjmu.edu.cn
Received: June 29, 2020
Peer-review started: June 29, 2020
First decision: October 21, 2020
Revised: November 16, 2020
Accepted: November 28, 2020
Article in press: November 28, 2020
Published online: January 26, 2021
Processing time: 205 Days and 16.8 Hours
Core Tip

Core Tip: Pancreatic regeneration is a potential therapeutic strategy for β cell recovery in diabetes. Previous studies have focused on the various cell types and different strategies for islet regeneration. However, how far this is from clinical application has not been fully elucidated. In this review, we focus on the clinical and preclinical agents used in different approaches. The clinical potential and disadvantages of the various approaches are discussed, and some suggestions are made for future perspectives.