Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2020; 12(9): 952-965
Published online Sep 26, 2020. doi: 10.4252/wjsc.v12.i9.952
Mechanotransduction of stem cells for tendon repair
Hao-Nan Wang, Yong-Can Huang, Guo-Xin Ni
Hao-Nan Wang, Guo-Xin Ni, School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China
Yong-Can Huang, Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Yong-Can Huang, National and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Author contributions: Wang HN and Huang YC contributed equally to this manuscript; Wang HN and Huang YC wrote the manuscript; Huang YC and Ni GX edited the manuscript and provided feedback.
Supported by National Natural Science Foundation of China, No. 81871848 and No. 81702171; and Shenzhen Double Chain Project for Innovation and Development Industry, No. 201806081018272960.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Guo-Xin Ni, PhD, Professor, School of Sport Medicine and Rehabilitation, Beijing Sport University, No. 48 Xinxi Road, Haidian District, Beijing 100084, China. niguoxin@bsu.edu.cn
Received: April 3, 2020
Peer-review started: April 3, 2020
First decision: April 22, 2020
Revised: May 6, 2020
Accepted: July 19, 2020
Article in press: July 19, 2020
Published online: September 26, 2020
Processing time: 171 Days and 16.4 Hours
Core Tip

Core Tip: Stem cells and mechanical loading are crucial to tendon injuries. In this review, we summarize the sources and roles of endogenous and exogenous stem cells for tendon repair, describe the mechanical response of stem cells, and finally highlight the mechanotransduction process and underlying signaling pathways. The deeper understanding of interactions between stem cells and mechanical loading offers great potential for the development of new therapeutic strategies for tendon repair.