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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly
Marta Camacho-Cardenosa, José Manuel Quesada-Gómez, Alba Camacho-Cardenosa, Alejo Leal, Gabriel Dorado, Bárbara Torrecillas-Baena, Antonio Casado-Díaz
Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Facultad Ciencias del Deporte, Universidad De Extremadura, Cáceres 10003, Spain
José Manuel Quesada-Gómez, Bárbara Torrecillas-Baena, Antonio Casado-Díaz, CIBER De Fragilidad Y Envejecimiento Saludable (CIBERFES), Unidad De Gestión Clínica De Endocrinología Y Nutrición, Instituto Maimónides De Investigación Biomédica De Córdoba, Hospital Universitario Reina Sofía, Córdoba 14004, Spain
Alejo Leal, Servicio de Traumatología, Hospital de Cáceres, Cáceres 10004, Spain
Gabriel Dorado, Departamento Bioquímica y Biología Molecular, Campus Rabanales C6-1-E17, Campus de Excelencia Internacional Agroalimentario (ceiA3), Universidad de Córdoba-CIBERFES, 14071 Córdoba, Spain
Author contributions: Camacho-Cardenosa M, Casado-Díaz A and Quesada-Gómez JM conceived and designed the experiments; Camacho-Cardenosa M, Torrecillas-Baena B and Casado-Díaz A performed the experiments in vitro; Camacho-Cardenosa M, Camacho-Cardenosa A and Leal A performed the studies with the elderly volunteers; Camacho-Cardenosa M, Casado-Díaz A, Dorado G and Quesada-Gómez JM wrote the paper. All authors analyzed and interpreted the data.
Supported by Government of Extremadura GAEDAF Research Group, No. GR18003; Ministerio de Educación, Cultura y Deporte, No. FPU15/00452; and Instituto de Salud Carlos III, No. PI15/01857 and No. PI18/01659.
Institutional review board statement: The study was approved by the Bioethical and Biosecurity Commission of the University of Extremadura (17/2016).
Conflict-of-interest statement: The authors have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Marta Camacho-Cardenosa, PhD, Postdoc, Facultad Ciencias Del Deporte, Universidad De Extremadura, Av. Universidad, s/n, Cáceres 10003, Spain. mcamachocardenosa@unex.es
Received: September 3, 2020
Peer-review started: September 3, 2020
First decision: September 15, 2020
Revised: September 30, 2020
Accepted: October 20, 2020
Article in press: October 20, 2020
Published online: December 26, 2020