Basic Study
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World J Stem Cells. Dec 26, 2020; 12(12): 1591-1602
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1591
Spinal cord injury regeneration using autologous bone marrow-derived neurocytes and rat embryonic stem cells: A comparative study in rats
Mir Sadat-Ali, Dakheel A Al-Dakheel, Ayesha Ahmed, Haifa A Al-Turki, Abdallah S Al-Omran, Sadananda Acharya, Methal I Al-Bayat
Mir Sadat-Ali, Department of Orthopedic Surgery, Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the University, Dammam 31952, Saudi Arabia
Dakheel A Al-Dakheel, Department of Orthopedic Surgery, Imam Abdulrahman Bin Faisal University, AlKhobar 31952, Saudi Arabia
Ayesha Ahmed, Methal I Al-Bayat, Department of Pathology, Imam Abdulrahman Bin Faisal University, Dammam 31952, Saudi Arabia
Haifa A Al-Turki, Department of Obstetrics and Gynecology, Imam Abdulrahman Bin Faisal University, Dammam 31142, Saudi Arabia
Abdallah S Al-Omran, Department of Orthopedic Surgery, Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the University, AlKhobar 31952, Saudi Arabia
Sadananda Acharya, Department of Public Health, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia
Author contributions: All authors participated equally from the inception to operative work, culturing neurocytes and histology.
Supported by King Abdulaziz City for Science and Technology, Riyadh vide, No. 10-MED1091-46.
Institutional animal care and use committee statement: The Committee of the Animal Care of the IAU gave the approval and monitored the study.
Conflict-of-interest statement: All authors have no conflicts of interest related to the manuscript.
Data sharing statement: The data are available for review at the dsr@iau.edu.sa.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mir Sadat-Ali, BM BCh, FRCS (Gen Surg), MBBS, MSc, PhD, Full Professor, Doctor, Department of Orthopedic Surgery, Imam Abdulrahman Bin Faisal University and King Fahd Hospital of the University, PO Box 40071, Dammam 31952, Saudi Arabia. drsadat@hotmail.com
Received: March 21, 2020
Peer-review started: March 21, 2020
First decision: August 22, 2020
Revised: August 24, 2020
Accepted: November 12, 2020
Article in press: November 12, 2020
Published online: December 26, 2020
Processing time: 280 Days and 11.9 Hours
Core Tip

Core Tip: We performed a comparative study of rats with iatrogenic SCI treated with control, rat embryonic stem cells and autologous bone marrow-derived neurocytes. Regeneration was assessed using three classic parameters and it was found that neurocytes were superior in the regeneration process.