Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2020; 12(12): 1553-1575
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1553
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1553
Minibrain-related kinase/dual-specificity tyrosine-regulated kinase 1B implication in stem/cancer stem cells biology
Nikolaos Kokkorakis, Maria Gaitanou, Laboratory of Cellular and Molecular Neurobiology-Stem Cells, Hellenic Pasteur Institute, Athens 11521, Greece
Author contributions: Kokkorakis Ν and Gaitanou M wrote the manuscript; All authors reviewed, edited and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maria Gaitanou, BSc, PhD, Research Assistant Professor, Laboratory of Cellular and Molecular Neurobiology-Stem Cells, Hellenic Pasteur Institute, Vas. Sofias 127, Athens 11521, Greece. mgaitanou@pasteur.gr
Received: July 10, 2020
Peer-review started: July 10, 2020
First decision: September 17, 2020
Revised: September 29, 2020
Accepted: October 15, 2020
Article in press: October 15, 2020
Published online: December 26, 2020
Peer-review started: July 10, 2020
First decision: September 17, 2020
Revised: September 29, 2020
Accepted: October 15, 2020
Article in press: October 15, 2020
Published online: December 26, 2020
Core Tip
Core Tip: Dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B), also known as minibrain-related kinase (MIRK) is the well-studied member of the DYRK kinase family. DYRK1B is a key regulator of signaling pathways that control proliferation and differentiation, and is critical for developmental processes and cell homeostasis. In this review, we aim to bring together what is known about the functional integration and cross-talk between DYRK1B and several pathways, such as sonic hedgehog, RAS and PI3K/mTOR/AKT pathways and how this might affect the behavior of stem cells in development and disease, taking into consideration potent therapeutic interventions and approaches.