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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2020; 12(11): 1237-1254
Published online Nov 26, 2020. doi: 10.4252/wjsc.v12.i11.1237
Published online Nov 26, 2020. doi: 10.4252/wjsc.v12.i11.1237
Role of platelets and breast cancer stem cells in metastasis
Gretel Mendoza-Almanza, CONACYT, Universidad Autónoma de Zacatecas., Zacatecas 98060, Mexico
Luis Burciaga-Hernández, Maestría en Ciencias Biomédicas, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico
Vilma Maldonado, Laboratorio de Epigenética, Instituto Nacional de Medicina Genómica, Ciudad de México 14610, Mexico
Jorge Melendez-Zajgla, Génómica funcional del cáncer, Instituto Nacional de Medicina Genómica, Ciudad de México 14610, Mexico
Jorge Olmos, Biotecnología Marina, Centro de Investigación Científica y de Estudios Superiores de Ensenada, Ensenada 22860, Mexico
Author contributions: All authors contributed equally to this paper with regard to cited literature and initial draft preparation; Mendoza-Almanza G and Olmos J were involved in manuscript conceptualization; all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jorge Olmos, DSc, Professor, Biotecnología Marina, Centro de Investigación Científica y de Estudios Superiores de Ensenada, Carretera Ensenada-Tijuana, Ensenada, Ensenada 22860, Mexico. jolmos@cicese.mx
Received: July 1, 2020
Peer-review started: July 1, 2020
First decision: August 9, 2020
Revised: August 23, 2020
Accepted: September 22, 2020
Article in press: September 22, 2020
Published online: November 26, 2020
Processing time: 148 Days and 4.4 Hours
Peer-review started: July 1, 2020
First decision: August 9, 2020
Revised: August 23, 2020
Accepted: September 22, 2020
Article in press: September 22, 2020
Published online: November 26, 2020
Processing time: 148 Days and 4.4 Hours
Core Tip
Core Tip: Cancer is a complex disease with several unknown mechanisms. The main aim of this work is to highlight the key role of platelets as communicator cells and their crucial role in cancer progression and second metastatic foci. This review focuses on the role of platelets in the tumor microenvironment as well as the interaction of molecules from platelets and breast cancer stem cells involved in cancer.