Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2019; 11(9): 666-676
Published online Sep 26, 2019. doi: 10.4252/wjsc.v11.i9.666
Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production
Xiao-Hua Lei, Yi-Qing Yang, Chi-Yuan Ma, En-Kui Duan
Xiao-Hua Lei, Chi-Yuan Ma, En-Kui Duan, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Yi-Qing Yang, Faculty of Laboratory Medical Science, Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Lei XH generated the figures and wrote the manuscript; Yang YQ contributed to the writing of the manuscript; Ma CY revised the manuscript; Duan EK designed the aim of the editorial and wrote the manuscript.
Supported by the National Natural Science Foundation of China Grants, No. 31600683 and No. U1738103; and Strategic Priority Research Program of the Chinese Academy of Sciences, No. XDA15014000.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Hua Lei, PhD, Senior Engineer, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China. leixh@ioz.ac.cn
Telephone: + 86-10-64807308 Fax: + 86-10-64807308
Received: February 15, 2019
Peer-review started: February 15, 2019
First decision: May 9, 2019
Revised: May 12, 2019
Accepted: August 26, 2019
Article in press: August 26, 2019
Published online: September 26, 2019
Processing time: 222 Days and 12.9 Hours
Core Tip

Core tip: Platelets derived from voluntary blood donation pose some challenges, such as susceptibility to pathogen contamination, short preservation time and difficulty in satisfying the increasing number of patients requiring platelet transfusion. Thus, seeking a safe and reliable alternative source of platelets is an effective solution.