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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2019; 11(8): 452-463
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.452
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.452
Neural regeneration by regionally induced stem cells within post-stroke brains: Novel therapy perspectives for stroke patients
Takayuki Nakagomi, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Takayuki Nakagomi, Tomohiro Matsuyama, Department of Therapeutic Progress in Brain Diseases, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Toshinori Takagi, Mikiya Beppu, Shinichi Yoshimura, Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Author contributions: Nakagomi T, Yoshimura S, and Matsuyama T participated in the conception of the manuscript. Nakagomi T and Takagi T wrote the manuscript. Nakagomi T, Beppu M, and Matsuyama T generated the figures. Nakagomi T edited the manuscript. All authors have read the manuscript and approved the final version.
Supported by Japan Society for the Promotion of Science (JSPS) KAKENHI , No. 15K06723 and No. 18K07380 .
Conflict-of-interest statement: Department of Therapeutic Progress in Brain Diseases is financially supported by Daiichi Sankyo Co., Ltd., Nippon Zoki Pharmaceutical Co., Ltd., and CLEA Japan, Inc. The sponsors had no roles in this study, including those of study design, data collection, data analysis, data interpretation, and manuscript writing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Takayuki Nakagomi, MD, PhD, Professor, Institute for Advanced Medical Sciences, Department of Therapeutic Progress in Brain Diseases, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo, 663-8501, Japan. nakagomi@hyo-med.ac.jp
Telephone: +81-798-456821 Fax: +81-798-456823
Received: February 26, 2019
Peer-review started: February 27, 2019
First decision: June 5, 2019
Revised: July 4, 2019
Accepted: July 16, 2019
Article in press: July 16, 2019
Published online: August 26, 2019
Processing time: 182 Days and 5.3 Hours
Peer-review started: February 27, 2019
First decision: June 5, 2019
Revised: July 4, 2019
Accepted: July 16, 2019
Article in press: July 16, 2019
Published online: August 26, 2019
Processing time: 182 Days and 5.3 Hours
Core Tip
Core tip: Ischemic stroke is a critical disease that is accompanied by serious symptoms, such as paresis. Until recently, it was believed that areas affected by stroke mainly consist of necrotic and inflammatory cells. However, we have recently demonstrated that novel ischemia-induced stem cells can be isolated from not only mouse brains after stroke but also human brains after stroke. These stem cells exhibited the multipotency and differentiated into electrophysiologically functional neurons. In this article, we introduce the future perspectives for patients suffering from ischemic stroke using these regionally derived stem cells.