Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2019; 11(7): 421-430
Published online Jul 26, 2019. doi: 10.4252/wjsc.v11.i7.421
Published online Jul 26, 2019. doi: 10.4252/wjsc.v11.i7.421
Induced pluripotent stem cells, a giant leap for mankind therapeutic applications
José Bragança, João André Lopes, Leonardo Mendes-Silva, João Miguel Almeida Santos, Department of Biomedical Sciences and Medicine, University of Algarve, Faro 8005-139, Portugal
José Bragança, João André Lopes, Leonardo Mendes-Silva, João Miguel Almeida Santos, Centre for Biomedical Research (CBMR), University of Algarve, Faro 8005-139, Portugal
José Bragança, ABC - Algarve Biomedical Centre, Faro 8005-139, Portugal
Author contributions: All authors contributed to this paper.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: José Bragança, PhD, Assistant Professor, Centre for Biomedical Research (CBMR), University of Algarve, Campus of Gambelas, Building 8, Room 2.22, Faro 8005-139, Portugal. jebraganca@ualg.pt
Telephone: +351-28-9800900-302317 Fax: +351-28-9800076
Received: February 22, 2019
Peer-review started: February 24, 2019
First decision: April 16, 2019
Revised: April 22, 2019
Accepted: June 12, 2019
Article in press: June 13, 2019
Published online: July 26, 2019
Processing time: 154 Days and 4.7 Hours
Peer-review started: February 24, 2019
First decision: April 16, 2019
Revised: April 22, 2019
Accepted: June 12, 2019
Article in press: June 13, 2019
Published online: July 26, 2019
Processing time: 154 Days and 4.7 Hours
Core Tip
Core tip: In this review, we present the current status on the basic and applied research involving induced pluripotent stem cells (iPSC). We discuss concerns around iPSC reprogramming technology, and present initiatives that have been recently developed for the use of iPSC in health-related issues. We also introduce some of the audacious clinical trials already ongoing to treat patients with cells derived from iPSC.