Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2019; 11(5): 254-269
Published online May 26, 2019. doi: 10.4252/wjsc.v11.i5.254
Mesenchymal stem cells for cartilage regeneration in dogs
Akari Sasaki, Mitsuru Mizuno, Manabu Mochizuki, Ichiro Sekiya
Akari Sasaki, Manabu Mochizuki, Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Mitsuru Mizuno, Ichiro Sekiya, Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan
Author contributions: Sasaki A, Mizuno M and Sekiya I conceptualized, designed and conducted the study; Sasaki A collected, analyzed and interpreted the data; drafting of the manuscript; Mizuno M, Mochizuki M and Sekiya I revised the manuscript; Sasaki A, Mizuno M, Mochizuki M and Sekiya I approved the final version of the manuscript.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Akari Sasaki, DVM, Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. akari.favorite@gmail.com
Telephone: +81-3-58415420 Fax: +81-3-58415405
Received: February 20, 2019
Peer-review started: February 20, 2019
First decision: March 15, 2019
Revised: March 29, 2019
Accepted: April 9, 2019
Article in press: April 9, 2019
Published online: May 26, 2019
Processing time: 95 Days and 19.3 Hours
Core Tip

Core tip: Mesenchymal stem cells (MSCs) are promising therapeutic tools for treatment of cartilage damage and osteoarthritis (OA). This review summarizes the current knowledge of MSCs from dogs, including in vitro characteristics, in vivo cartilage regenerative potential, and therapeutic effects for naturally developed OA in dogs. MSCs from dogs share many in vivo characteristics with MSCs from other animal species and are reported to have excellent cartilage repair potential in experimental and clinical situations. The article also describes the current limitations of MSC use in dogs that remain to be resolved in the future.