Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2019; 11(3): 147-166
Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.147
Adipose-derived stromal/stem cells from different adipose depots in obesity development
Karina Ribeiro Silva, Leandra Santos Baptista
Karina Ribeiro Silva, Leandra Santos Baptista, Laboratory of Tissue Bioengineering, Directory of Metrology Applied to Life Sciences, National Institute of Metrology, Quality and Technology, Duque de Caxias, RJ 25250-020, Brazil
Karina Ribeiro Silva, Leandra Santos Baptista, Post-Graduation Program of Biotechnology, National Institute of Metrology, Quality and Technology, Duque de Caxias, RJ 25250-020, Brazil
Leandra Santos Baptista, Multidisciplinary Center for Biological Research (Numpex-Bio), Federal University of Rio de Janeiro Campus Duque de Caxias, Duque de Caxias, RJ 25245-390, Brazil
Author contributions: Silva KR drafted the article, contributed to the conception and design of the manuscript, wrote the article and approved the final version; Baptista LS drafted the article, contributed to the conception and design of the manuscript, contributed to the writing of the manuscript, made critical revisions related to relevant intellectual content of the manuscript and approved the final version of the article.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Leandra Santos Baptista, PhD, Professor, Laboratory of Tissue Bioengineering, Directory of Metrology Applied to Life Sciences, National Institute of Metrology, Quality and Technology, Duque de Caxias, RJ 25250-020, Brazil. leandra.baptista@gmail.com
Telephone: +55-21-21453151
Received: September 29, 2018
Peer-review started: September 29, 2018
First decision: October 19, 2018
Revised: January 27, 2019
Accepted: February 28, 2019
Article in press: February 28, 2019
Published online: March 26, 2019
Processing time: 178 Days and 5 Hours
Core Tip

Core tip: White adipose tissue (WAT) depots at different anatomical locations are highly heterogeneous in morphology and phenotype, and contribute differently to the development of obesity and metabolic disorders. Here, we discuss the role of adipose-derived stem/stromal cells (ASC) in the development of obesity and metabolic disorders, by reviewing the data suggesting that depot-specific ASC/adipose progenitor cells help to develop the specific responses of each WAT depot to metabolic challenges. In particular, we address the importance of ASC-dependent immunomodulation in the inflammatory response associated with obesity, providing guidance for future research on the use ASC-based therapeutic approaches.