Holan V, Hermankova B, Krulova M, Zajicova A. Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells - a clue to stem cell-based therapy. World J Stem Cells 2019; 11(11): 957-967 [PMID: 31768222 DOI: 10.4252/wjsc.v11.i11.957]
Corresponding Author of This Article
Vladimir Holan, PhD, Professor, Department of Transplantation Immunology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic. vladimir.holan@iem.cas.cz
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Nov 26, 2019; 11(11): 957-967 Published online Nov 26, 2019. doi: 10.4252/wjsc.v11.i11.957
Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells - a clue to stem cell-based therapy
Vladimir Holan, Barbora Hermankova, Magdalena Krulova, Alena Zajicova
Vladimir Holan, Barbora Hermankova, Magdalena Krulova, Alena Zajicova, Department of Transplantation Immunology, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague 14220, Czech Republic
Vladimir Holan, Barbora Hermankova, Magdalena Krulova, Department of Cell Biology, Faculty of Science, Charles University, Prague 12843, Czech Republic
Author contributions: All authors reviewed the literature, contributed to writing, and approved the manuscript.
Supported bythe Grant Agency of the Czech Republic, No. 17-04800S, No. 18-04393S, No. 19-02290S; the Ministry of Education, Youth and Sports of the Czech Republic, No. SVV 244-260435, No. NPU-I: LO1508, No. NPU-I: LO1309.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Vladimir Holan, PhD, Professor, Department of Transplantation Immunology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic. vladimir.holan@iem.cas.cz
Telephone: +420-241063226
Received: May 25, 2019 Peer-review started: May 27, 2019 First decision: July 31, 2019 Revised: September 2, 2019 Accepted: September 13, 2019 Article in press: September 13, 2019 Published online: November 26, 2019 Processing time: 165 Days and 2.1 Hours
Core Tip
Core tip: Cell-based therapy using autologous mesenchymal stem cells represents a perspective approach for the treatment of so far incurable degenerative retinal diseases. However, the therapeutic potential of mesenchymal stem cells strongly depends on the cytokine environment, where these cells are delivered. In this study, we discuss recent knowledge regarding the interactions and interplay among cytokines produced by cells of the diseased retina, inflammatory immune cells and therapeutically administered mesenchymal stem cells. We suggest that these interactions among cytokines and growth factors occurring in the microenvironment of the diseased retina could be critical for the outcome of the stem cell-based therapy for retinal disorders.
