Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Oct 26, 2019; 11(10): 891-903
Published online Oct 26, 2019. doi: 10.4252/wjsc.v11.i10.891
Stem cell treatment and cerebral palsy: Systemic review and meta-analysis
Simone Eggenberger, Céline Boucard, Andreina Schoeberlein, Raphael Guzman, Andreas Limacher, Daniel Surbek, Martin Mueller
Simone Eggenberger, Daniel Surbek, Martin Mueller, Department of Obstetrics and Gynaecology, Inselspital, University Hospital Bern, Bern 3010, Switzerland
Céline Boucard, Andreina Schoeberlein, Department for BioMedical Research, University of Bern, Bern 3008, Switzerland
Raphael Guzman, Department of Neurosurgery, University Hospital of Basel, Basel 4056, Switzerland
Andreas Limacher, CTU Bern, University of Bern, Bern 3012, Switzerland
Author contributions: Eggenberger S and Mueller M drafted and wrote the manuscript; Limacher A performed the statistical analysis; Guzman R, Boucard C, Schoeberlein A, Limacher A and Surbek D revised and provided critical and important intellectual content; all authors have given final approval of the version to be published.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Martin Mueller, MD, PhD, Senior Consultant, Department of Obstetrics and Gynaecology, Inselspital, University Hospital Bern, Friedbühlstrasse 19, Bern 3010, Switzerland.
Telephone: +41-31-6321125 Fax: +41-31-6321128
Received: March 12, 2019
Peer-review started: March 15, 2019
First decision: June 3, 2019
Revised: June 12, 2019
Accepted: August 20, 2019
Article in press: August 20, 2019
Published online: October 26, 2019
Core Tip

Core tip: Cerebral palsy is a severe motor disability resulting from perinatal complications. Recently, stem cell therapy emerged as a promising treatment option and raised hope in patients and their families. However, high-quality randomized clinical trials investigating the efficacy of stem cell therapy as a treatment for cerebral palsy are scarce. We included the small number of currently available trials in our meta-analysis. A slight but significantly positive effect on the gross motor function favoring the stem cell group can be seen.