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World J Stem Cells. Oct 26, 2019; 11(10): 764-786
Published online Oct 26, 2019. doi: 10.4252/wjsc.v11.i10.764
Effect of poly(3-hydroxyalkanoates) as natural polymers on mesenchymal stem cells
Vera Voinova, Garina Bonartseva, Anton Bonartsev
Vera Voinova, Anton Bonartsev, Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow 119234, Russia
Garina Bonartseva, Anton Bonartsev, A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia
Author contributions: All authors contributed to the design and writing of the paper, literature review and analysis, revision, and approval of the final version.
Supported by Russian Science Foundation, No. 17-74-20104.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Anton Bonartsev, PhD, Assistant Lecturer, Faculty of Biology, M.V. Lomonosov Moscow State University, Leninskie gory 1, bld. 12, Moscow 119234, Russia.
Telephone: +7-916-6126232
Received: March 18, 2019
Peer-review started: March 20, 2019
First decision: April 16, 2019
Revised: May 17, 2019
Accepted: August 27, 2019
Article in press: August 27, 2019
Published online: October 26, 2019
Core Tip

Core tip: Biodegradable and biocompatible polymers, poly(3-hydroxyalkanoates) (PHAs), are actively used for the manufacture of scaffolds that serve as carriers for mesenchymal stem cell growth in tissue engineering. It was shown that PHAs have their own biological activity affecting mesenchymal stem cell growth and differentiation. However, the mechanisms of the biological activity of PHAs remain unclear. In this review, we discuss the possible association of the effects of bacteria-originating PHAs on mesenchymal stem cells with various biological functions of PHAs in bacteria and eukaryotes, including in humans.