Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2019; 11(1): 33-43
Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.33
Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes
Pranav Machiraju, Steven C Greenway
Pranav Machiraju, Departments of Pediatrics and Cardiac Sciences, Alberta Children’s Hospital Research Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada
Steven C Greenway, Departments of Pediatrics, Cardiac Sciences, Biochemistry & Molecular Biology, Alberta Children’s Hospital Research Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada
Author contributions: Both authors surveyed literature, wrote, and approved the manuscript.
Supported by Children’s Cardiomyopathy Foundation, No. 2017.
Conflict-of-interest statement: Authors have no conflicts to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Steven C Greenway, MSc, MD, FRCPC, Section of Cardiology, Alberta Children’s Hospital, 28 Oki Drive NW, Calgary T3B 6A8, Canada. scgreenw@ucalgary.ca
Telephone: 1-403-9555049 Fax: 1-403-9557621
Received: October 30, 2018
Peer-review started: October 30, 2018
First decision: November 15, 2018
Revised: November 24, 2018
Accepted: January 10, 2019
Article in press: January 10, 2019
Published online: January 26, 2019
Processing time: 88 Days and 10.1 Hours
Core Tip

Core tip: Induced pluripotent stem cells are key for generating disease-, patient-, and tissue-specific in vitro models. As such, induced pluripotent stem cells differentiated into cardiomyocytes offer a potential tool for the understanding of disease and the development of life-saving therapeutics. Currently, cardiomyocytes can be differentiated with high efficiency but remain immature in their structure and function. Maturation of these cells is possible using a variety of approaches and will allow for more accurate disease modeling.