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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2018; 10(7): 82-105
Published online Jul 26, 2018. doi: 10.4252/wjsc.v10.i7.82
Published online Jul 26, 2018. doi: 10.4252/wjsc.v10.i7.82
Stem cell therapy for faecal incontinence: Current state and future perspectives
Jacobo Trébol, General and Digestive Tract Surgery Department, Salamanca University Healthcare Centre, Salamanca 37007, Spain
Ana Carabias-Orgaz, Anaesthesiology Department, Complejo Asistencial de Ávila, Ávila 05004, Spain
Mariano García-Arranz, New Therapies Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid 28040, Spain
Damián García-Olmo, General and Digestive Tract Surgery Department, Quiron-Salud Hospitals, Madrid 28040, Spain
Damián García-Olmo, Surgery Department, Universidad Autónoma, Madrid 28040, Spain
Author contributions: All authors equally contributed to this paper with drafting and critical revision; Trébol J performed literature review and analysis; Carabias-Orgaz A revised language editing; Trébol J and Carabias-Orgaz A wrote the paper; all authors reviewed the paper and gave their final approval of manuscript.
Conflict-of-interest statement: García-Olmo D is member of the Advisory Board of Tigenix S.A.U. and co-holds patent rights about biomaterial for suturing (P200402083-Spain, 04380271.9-Europe and 101573.55823US-United States). García-Olmo D and García-Arranz M co-hold patent rights for “Use of adipose tissue-derived stromal stem cells for treating fistula” (PL2944688 T3-Europe and US2006045872 A1-United States). Other authors indicated no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jacobo Trébol, MD, PhD, Surgeon, Surgical Oncologist, General and Digestive Tract Surgery Department, Salamanca University Healthcare Centre, Paseo de San Vicente, No. 58-182, Salamanca 37007, Spain. jtrebol@saludcastillayleon.es
Telephone: +34-92-3291634
Received: May 22, 2018
Peer-review started: May 23, 2018
First decision: June 14, 2018
Revised: June 26, 2018
Accepted: June 30, 2018
Article in press: June 30, 2018
Published online: July 26, 2018
Processing time: 65 Days and 22.9 Hours
Peer-review started: May 23, 2018
First decision: June 14, 2018
Revised: June 26, 2018
Accepted: June 30, 2018
Article in press: June 30, 2018
Published online: July 26, 2018
Processing time: 65 Days and 22.9 Hours
Core Tip
Core tip: Faecal incontinence is very frequent and is associated with severe consequences for patients. Available treatment outcomes are not optimal, particularly in the long-term. Stem cells, with or without bioengineering, could improve these results, as demonstrated in other clinical settings. We present a descriptive review of the published literature about faecal incontinence and stem cells, and discuss the existing limitations and concerns. Preclinical studies have confirmed the feasibility and safety of stem cells, and show some interesting results; the limited clinical experience confirms the safety and potential efficacy. However, further studies are needed to obtain clear conclusions.