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World J Stem Cells. Feb 26, 2018; 10(2): 15-22
Published online Feb 26, 2018. doi: 10.4252/wjsc.v10.i2.15
Spatiotemporal switching signals for cancer stem cell activation in pediatric origins of adulthood cancer: Towards a watch-and-wait lifetime strategy for cancer treatment
Shengwen Calvin Li, Mustafa H Kabeer
Shengwen Calvin Li, Neuro-oncology and Stem Cell Research Laboratory, Children’s Hospital of Orange County, Department of Neurology, University of California-Irvine School of Medicine, Orange, CA 92868-3874, United States
Mustafa H Kabeer, Children's Hospital of Orange County, Department of Surgery, University of California-Irvine School of Medicine, Orange, CA 92868-3874, United States
Author contributions: Li SC conceived the project and wrote the primary manuscript; Li SC and Kabeer MH revised the manuscript.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shengwen Calvin Li, PhD, Principal Investigator (Scientist), Neuro-oncology and Stem Cell Research Laboratory, Children’s Hospital of Orange County, Department of Neurology, University of California-Irvine School of Medicine, 455 South Main Street, Orange, CA 92868-3874, United States. shengwel@uci.edu
Telephone: +1-714-5094964 Fax: +1-714-5094318
Received: December 22, 2017
Peer-review started: December 23, 2017
First decision: January 6, 2018
Revised: January 25, 2018
Accepted: February 24, 2018
Article in press: February 25, 2018
Published online: February 26, 2018
Core Tip

Core tip: How does “spatiotemporal tracking of cancer stem cells” should be achieved in an organism for pediatric origins of adult cancer? Improving the resolution of current imaging technologies down to the single cell level is essential. However, how single cells could be tracked label-free throughout the lifetime of a human body will be challenging. Such technologies, if developed, can potentially provide an evidence base for cancer prevention and treatment.