Shi HS, Yuan X, Wu FF, Li XY, Fan WJ, Yang X, Hu XM, Liu GB. Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives. World J Stem Cells 2024; 16(1): 33-53 [PMID: 38292441 DOI: 10.4252/wjsc.v16.i1.33]
Corresponding Author of This Article
Guo-Bin Liu, MD, Doctor, Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai 250021, China. 15800885533@163.com
Research Domain of This Article
Peripheral Vascular Disease
Article-Type of This Article
Scientometrics
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hong-Shuo Shi, Xin Yuan, Fang-Fang Wu, Xiao-Yu Li, Wei-Jing Fan, Xiao Yang, Xiao-Ming Hu, Guo-Bin Liu, Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 250021, China
Author contributions: Liu GB, Yang X, and Fan WJ proposed the research design; Shi HS and Yuan X conducted the literature search, publication screening, and data extraction; Shi HS carried out the data analysis; Wu FF and Li XY conducted manuscript revisions; Hu XM made important contributions to the editing and illustration of this manuscript; The authors collectively contributed to and endorsed the final version of the article.
Supported by: The study was funded by the National Natural Science Foundation of China (82274528); Construction Task Book for the Three-Year Action Plan for Accelerating the Inheritance and Innovative Development of Traditional Chinese Medicine in Shanghai (2021-2023) (ZY(2021-2023)-0211); Shanghai Municipal Health Commission Scientific Research Programme Mission Statement (202240228); Special Youth Project for Clinical Research of Shanghai Municipal Health Commission (20234Y0162); Clinical Research Talent Training Program of Shanghai University of Traditional Chinese Medicine Affiliated Hospital (2023LCRC06); Four Bright Foundations of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (SGKJ-202301); Shanghai Pudong New Area Health and Family Planning Commission’s Pudong Famous TCM Cultivation Program project (PWRZM2020-18).
Conflict-of-interest statement: The authors declare having no conflicts of interest in relation to this manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Bin Liu, MD, Doctor, Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Pudong New Area, Shanghai 250021, China. 15800885533@163.com
Received: September 23, 2023 Peer-review started: September 23, 2023 First decision: November 22, 2023 Revised: December 6, 2023 Accepted: December 28, 2023 Article in press: December 28, 2023 Published online: January 26, 2024 Processing time: 121 Days and 2.1 Hours
ARTICLE HIGHLIGHTS
Research background
Stem cell therapy has shown great potential for treating diabetic foot (DF).
Research motivation
There is currently a lack of comprehensive research in this field.
Research objectives
The purpose of this study was to conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades, with the aim of depicting the current global research landscape, identifying the most influential research hotspots, and providing insights for future research directions.
Research methods
We searched the Web of Science Core Collection database for all relevant studies on the use of stem cell therapy in DF. Bibliometric analysis was carried out using CiteSpace, VOSviewer, and R (4.3.1) to identify the most notable studies.
Research results
A search was conducted to identify publications related to the use of stem cells for DF treatment. A total of 542 articles published from 2000 to 2023 were identified. The United States had published the most papers on this subject. In this field, Iran’s Shahid Beheshti University Medical Sciences demonstrated the highest productivity. Furthermore, Dr. Bayat from the same university has been an outstanding researcher in this field. Stem Cell Research & Therapy was the journal with the highest number of publications in this field. The main keywords were “diabetic foot ulcers,” “wound healing,” and “angiogenesis.”
Research conclusions
This study systematically illustrated the advances in the use of stem cell therapy to treat DF over the past 23 years. Current research findings suggested that the hotspots in this field included stem cell dressings, exosomes, wound healing, and adipose-derived stem cells.
Research perspectives
Future research should also focus on the clinical translation of stem cell therapies for DF.
