Published online Sep 26, 2017. doi: 10.4252/wjsc.v9.i9.144
Peer-review started: February 13, 2017
First decision: May 11, 2017
Revised: June 29, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: September 26, 2017
Peripheral nerve injury has remained a substantial clinical complication with no satisfactory treatment options. Despite the great development in the field of microsurgery, some severe types of neural injuries cannot be treated without causing tension to the injured nerve. Thus current studies have focused on the new approaches for the treatment of peripheral nerve injuries. Stem cells with the ability to differentiate into a variety of cell types have brought a new perspective to this matter. In this review, we will discuss the use of three main sources of mesenchymal stem cells in the treatment of peripheral nerve injuries.
Core tip: Mesenchymal stem cells (MSCs) can differentiate into many kinds of cell types including Schwann cells (SCs). Since there are limitations for the use of SCs in nerve injuries, it is necessary to know about substitute cell types. So far different sources of MSCs such as embryonic stem cells, bone marrow MSCs, adipose-derived stem cells, etc. have been studied and the existence of beneficial effects on nerve regeneration after injury has been confirmed. Here in this paper, we have collected the latest updates on the use of MSCs from different sources in peripheral nerve regeneration.