Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2017; 9(8): 107-117
Published online Aug 26, 2017. doi: 10.4252/wjsc.v9.i8.107
Adipose-derived stromal cell in regenerative medicine: A review
Reza Tabatabaei Qomi, Mohsen Sheykhhasan
Reza Tabatabaei Qomi, Mohsen Sheykhhasan, Department of Stem Cell, the Academic Center for Education, Culture and Research, PO Box QOM-3713189934, Qom, Iran
Author contributions: Tabatabaei Qomi R performed the majority of the writing prepared the figures and tables; Sheykhhasan M performed data accusation and writing; Tabatabaei Qomi R provided the input in writing the paper; Sheykhhasan M designed the outline and coordinated the writing of the paper.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Mohsen Sheykhhasan, MS, Department of Stem Cell, the Academic Center for Education, Culture and Research, Qom Branch, PO Box QOM-3713189934, Qom, Iran.
Telephone: +98-253-2700152 Fax: +98-253-2700155
Received: January 27, 2017
Peer-review started: February 12, 2017
First decision: March 10, 2017
Revised: April 30, 2017
Accepted: May 18, 2017
Article in press: May 19, 2017
Published online: August 26, 2017

The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine. Such as, several stromal cells have been employed as treat option for regenerative medicine. For example, human bone marrow-derived stromal cells and adipose-derived stromal cells (ADSCs) are used in cell-based therapy. Data relating to the stem cell therapy and processes associated with ADSC has developed remarkably in the past 10 years. As medical options, both the stromal vascular and ADSC suggests good opportunity as marvelous cell-based therapeutics. The some biological features are the main factors that impact the regenerative activity of ADSCs, including the modulation of the cellular immune system properties and secretion of bioactive proteins such as cytokines, chemokines and growth factors, as well as their intrinsic anti-ulcer and anti-inflammatory potential. A variety of diseases have been treated by ADSCs, and it is not surprising that there has been great interest in the possibility that ADSCs might be used as therapeutic strategy to improve a wider range of diseases. This is especially important when it is remembered that routine therapeutic methods are not completely effective in treat of diseases. Here, it was discuss about applications of ADSC to colitis, liver failure, diabetes mellitus, multiple sclerosis, orthopaedic disorders, hair loss, fertility problems, and salivary gland damage.

Keywords: Adipose-derived stromal cell, Colitis disease, Liver failure, Diabetes mellitus, Multiple sclerosis, Orthopedic disorders, Hair loss, Fertility problems, Salivary gland damage

Core tip: Nowadays, adipose-derived stromal cells (ADSCs) are one of the most important and promising cell sources in the field of regenerative medicine. Unique capabilities of ADSCs caused them to be used in both research and treatment as a valuable resource in basic science and medical researches. In over 15 years since their discovery, ADSCs have transformed our toolkit for treating human disorder and disease. As the field enters its next decade, a new wave of therapeutic applications, such as hepatic regeneration, diabetes mellitus treatment, multiple sclerosis treatment, and orthopaedic disorders regeneration, has converged with ADSCs to yield new insights for their use in stem cell engineering and regenerative medicine.