Foroglou P, Karathanasis V, Demiri E, Koliakos G, Papadakis M. Role of adipose-derived stromal cells in pedicle skin flap survival in experimental animal models. World J Stem Cells 2016; 8(3): 101-105 [PMID: 27022440 DOI: 10.4252/wjsc.v8.i3.101]
Corresponding Author of This Article
Marios Papadakis, MD, PhD, Department of Surgery, Helios Clinic, University Hospital Witten-Herdecke, Heusnerstr 40, 42283 Wuppertal, Germany. marios_papadakis@yahoo.gr
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Mar 26, 2016; 8(3): 101-105 Published online Mar 26, 2016. doi: 10.4252/wjsc.v8.i3.101
Role of adipose-derived stromal cells in pedicle skin flap survival in experimental animal models
Pericles Foroglou, Vasileios Karathanasis, Efterpi Demiri, George Koliakos, Marios Papadakis
Pericles Foroglou, Vasileios Karathanasis, Efterpi Demiri, Department of Plastic Surgery, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
George Koliakos, Department of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Marios Papadakis, Department of Surgery, Helios Clinic, University Hospital Witten-Herdecke, 42283 Wuppertal, Germany
Author contributions: Foroglou P, Karathanasis V and Papadakis M designed the research; Karathanasis V, Demiri E, Koliakos G and Papadakis M performed the research; Foroglou P and Karathanasis V wrote the paper; all authors critically reviewed and approved of the final version.
Conflict-of-interest statement: We declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Marios Papadakis, MD, PhD, Department of Surgery, Helios Clinic, University Hospital Witten-Herdecke, Heusnerstr 40, 42283 Wuppertal, Germany. marios_papadakis@yahoo.gr
Telephone: +49-157-35800318
Received: September 18, 2015 Peer-review started: September 22, 2015 First decision: November 27, 2015 Revised: December 23, 2015 Accepted: January 21, 2016 Article in press: January 22, 2016 Published online: March 26, 2016
Abstract
The use of skin flaps in reconstructive surgery is the first-line surgical treatment for the reconstruction of skin defects and is essentially considered the starting point of plastic surgery. Despite their excellent usability, their application includes general surgical risks or possible complications, the primary and most common is necrosis of the flap. To improve flap survival, researchers have used different methods, including the use of adipose-derived stem cells, with significant positive results. In our research we will report the use of adipose-derived stem cells in pedicle skin flap survival based on current literature on various experimental models in animals.
Core tip: The use of skin flaps in reconstructive surgery is the first-line surgical treatment for the reconstruction of skin defects and is essentially considered the starting point of plastic surgery. Our work, summarizing the current literature, presents the role of adipose-derived stromal cells in pedicle skin flap survival in experimental animal models.
