Hishikawa K, Takase O, Yoshikawa M, Tsujimura T, Nangaku M, Takato T. Adult stem-like cells in kidney. World J Stem Cells 2015; 7(2): 490-494 [PMID: 25815133 DOI: 10.4252/wjsc.v7.i2.490]
Corresponding Author of This Article
Keiichi Hishikawa, MD, PhD, Department of Advanced Nephrology and Regenerative Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. hishikawa-tky@umin.ac.jp
Research Domain of This Article
Cell Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan
Tsuyoshi Takato, Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan
Author contributions: All authors contributed to this paper.
Conflict-of-interest: All authors certify that there is no conflict of interest (including but not limited to commercial, personal, political, intellectual, or religious) regarding the material discussed in the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Keiichi Hishikawa, MD, PhD, Department of Advanced Nephrology and Regenerative Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan. hishikawa-tky@umin.ac.jp
Telephone: +81-3-3155411
Received: July 29, 2014 Peer-review started: July 30, 2014 First decision: October 16, 2014 Revised: November 20, 2014 Accepted: December 3, 2014 Article in press: December 10, 2014 Published online: March 26, 2015
Abstract
Human pluripotent cells are promising for treatment for kidney diseases, but the protocols for derivation of kidney cell types are still controversial. Kidney tissue regeneration is well confirmed in several lower vertebrates such as fish, and the repair of nephrons after tubular damages is commonly observed after renal injury. Even in adult mammal kidney, renal progenitor cell or system is reportedly presents suggesting that adult stem-like cells in kidney can be practical clinical targets for kidney diseases. However, it is still unclear if kidney stem cells or stem-like cells exist or not. In general, stemness is defined by several factors such as self-renewal capacity, multi-lineage potency and characteristic gene expression profiles. The definite use of stemness may be obstacle to understand kidney regeneration, and here we describe the recent broad findings of kidney regeneration and the cells that contribute regeneration.
Core tip: Controversies still persist whether kidney stem cells exist or not, but renal progenitor cell or system is reportedly presents suggesting that adult stem-like cells in kidney can be practical clinical targets for kidney diseases. In this mini-review, we describe the recent broad findings of kidney regeneration and the cells that contribute regeneration.
