Rong J, Li YY, Wang X, Wang JN, Song M. Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing. World J Stem Cells 2025; 17(4): 102917 [DOI: 10.4252/wjsc.v17.i4.102917]
Corresponding Author of This Article
Mei Song, PhD, Chief Physician, Department of Burns and Plastic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, No. 333 Nanbin Road, Qilihe District, Lanzhou 730050, Gansu Province, China. esm109@126.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Apr 26, 2025; 17(4): 102917 Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.102917
Non-coding RNAs in adipose-derived stem cell exosomes: Mechanisms, therapeutic potential, and challenges in wound healing
Jian Rong, Yao-Yao Li, Xin Wang, Jia-Ning Wang, Mei Song
Jian Rong, Yao-Yao Li, Xin Wang, Jia-Ning Wang, Mei Song, Department of Burns and Plastic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou 730050, Gansu Province, China
Jian Rong, Yao-Yao Li, Xin Wang, Jia-Ning Wang, Mei Song, Department of Plateau Medicine, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, Lanzhou 730050, Gansu Province, China
Author contributions: Rong J conceptualized the work and wrote the original draft; Song M wrote, edited, and revised the paper; Li YY and Wang X were partially involved in writing the original draft; Wang JN was responsible for the article’s figures. All the authors have read and agreed to the published version of the manuscript.
Supported by the Intra-Hospital Project of No. 940 Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, No. 2021yxky016.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mei Song, PhD, Chief Physician, Department of Burns and Plastic Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army, No. 333 Nanbin Road, Qilihe District, Lanzhou 730050, Gansu Province, China. esm109@126.com
Received: November 5, 2024 Revised: December 23, 2024 Accepted: March 21, 2025 Published online: April 26, 2025 Processing time: 172 Days and 14 Hours
Abstract
The treatment of complex wounds presents a significant clinical challenge due to the limited availability of standardized therapeutic options. Adipose-derived stem cell exosomes (ADSC-Exos) are promising for their capabilities to enhance angiogenesis, mitigate oxidative stress, modulate inflammatory pathways, support skin cell regeneration, and promote epithelialization. These exosomes deliver non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, which facilitate collagen remodeling, reduce scar formation, and expedite wound healing. This study reviews the mechanisms, therapeutic roles, and challenges of non-coding RNA-loaded ADSC-Exos in wound healing and identifies critical directions for future research. It aims to provide insights for researchers into the potential mechanisms and clinical applications of ADSC-Exos non-coding RNAs in wound healing.
Core Tip: Wound healing progresses through four interrelated phases: Haemostasis, inflammation, proliferation, and remodelling. These phases are highly coordinated and synergistic, facilitating tissue repair. In recent years, it has been found that non-coding RNAs derived from adipose-derived stem cell exosomes promote wound healing via working on various stages of wound healing. This review explores the mechanisms, functions, and challenges of non-coding RNAs derived from adipose-derived stem cell exosomes in wound healing, providing a theoretical basis and suggested directions for further basic research and clinical applications of these exosomes.
