Zhang JW. Impact of miR-214-5p and miR-21-5p from hypoxic endometrial exosomes on human umbilical cord mesenchymal stem cell function. World J Stem Cells 2025; 17(2): 102404 [DOI: 10.4252/wjsc.v17.i2.102404]
Corresponding Author of This Article
Jin-Wei Zhang, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China. jinweizhang@sioc.ac.cn
Research Domain of This Article
Biology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Feb 26, 2025; 17(2): 102404 Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.102404
Impact of miR-214-5p and miR-21-5p from hypoxic endometrial exosomes on human umbilical cord mesenchymal stem cell function
Jin-Wei Zhang
Jin-Wei Zhang, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Jin-Wei Zhang, Institute of Biomedical and Clinical Sciences, Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4PS, United Kingdom
Author contributions: Zhang JW designed the overall concept and outline of the manuscript, contributed to the discussion and design of the manuscript, and contributed to the writing and editing of the manuscript, illustrations, and review of the literature.
Supported by the National Natural Science Foundation of China, No. 82170406 and No. 81970238; and the Royal Society United Kingdom, No. IEC\NSFC\201094.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Wei Zhang, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China. jinweizhang@sioc.ac.cn
Received: October 16, 2024 Revised: December 21, 2024 Accepted: January 16, 2025 Published online: February 26, 2025 Processing time: 130 Days and 20.8 Hours
Abstract
Exosomes derived from hypoxic endometrial epithelial cells are pivotal in cellular communication and tissue repair, offering new perspectives on reproductive health. This manuscript highlights the study by Zhang et al, which investigates the effects of miR-214-5p and miR-21-5p in hypoxic cell-derived exosomes on human umbilical cord mesenchymal stem cells. The study reveals that low levels of these microRNAs activate the signal transducer and activator of transcription 3 signaling pathway, enhancing human umbilical cord mesenchymal stem cell migration and differentiation. These findings provide novel insights into therapeutic strategies for improving endometrial health and addressing infertility linked to thin endometrium.
Core Tip: This manuscript examines the study by Zhang et al on the effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells. The study highlights how low expression levels of these microRNAs activate the signal transducer and activator of transcription 3 signaling pathway, promoting human umbilical cord mesenchymal stem cell migration and differentiation - key processes in tissue repair and regeneration. These findings offer new insights into addressing thin endometrium, a common cause of infertility, by leveraging exosome-based therapies or targeted microRNA modulation. This article underscores the potential of miR-214-5p and miR-21-5p as therapeutic targets for improving endometrial health and reproductive outcomes.
