Liu ZH, Xie QQ, Huang JL. Stromal vascular fraction: Mechanisms and application in reproductive disorders. World J Stem Cells 2025; 17(1): 101097 [DOI: 10.4252/wjsc.v17.i1.101097]
Corresponding Author of This Article
Jia-Lyu Huang, MD, PhD, Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, No. 508 Xizhan Street, Nanchang 330008, Jiangxi Province, China. huangjialv_medicine@foxmail.com
Research Domain of This Article
Reproductive Biology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jan 26, 2025; 17(1): 101097 Published online Jan 26, 2025. doi: 10.4252/wjsc.v17.i1.101097
Stromal vascular fraction: Mechanisms and application in reproductive disorders
Zhi-Han Liu, Qi-Qi Xie, Jia-Lyu Huang
Zhi-Han Liu, Department of Clinical Medicine, School of Queen Mary, Nanchang University, Nanchang 330000, Jiangxi Province, China
Qi-Qi Xie, Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang 330000, Jiangxi Province, China
Jia-Lyu Huang, Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang 330008, Jiangxi Province, China
Co-first authors: Zhi-Han Liu and Qi-Qi Xie.
Author contributions: Liu ZH and Xie QQ contributed equally to the literature review and manuscript drafting as co-first authors; Huang JL conceptualized and revised the manuscript; and all authors read and agreed to the published version of the manuscript.
Supported by the Natural Science Foundation of Jiangxi Province, No. 20224BAB216025; and National Natural Science Foundation of China, No. 82260315.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Lyu Huang, MD, PhD, Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, No. 508 Xizhan Street, Nanchang 330008, Jiangxi Province, China. huangjialv_medicine@foxmail.com
Received: September 4, 2024 Revised: December 2, 2024 Accepted: December 20, 2024 Published online: January 26, 2025 Processing time: 137 Days and 19 Hours
Abstract
Stromal vascular fraction (SVF) is a complex mixture derived from adipose tissue, consisting of a variety of cells. Due to its potential for tissue repair, immunomodulation, and support of angiogenesis, SVF represents a promising frontier in regenerative medicine and offers potential therapy for a range of disease conditions. In this article, we delve into the mechanisms through which SVF exerts its effects and explore its potential applications in treating both male and female reproductive disorders, including erectile dysfunction, testicular injury, stress urinary incontinence and intrauterine adhesion.
Core Tip: This article will analyze the minireview by Jeyaraman et al, with a focus on the future direction of stromal vascular fraction (SVF) for reproductive therapy. SVF received increasing attention for its multi-faceted function including immunomodulation, pro-angiogenesis and tissue repair. By reviewing the current research in the field of erectile dysfunction, testicular injury, intrauterine adhesion, and stress urinary incontinence, we highlight the opportunities of SVF in treating reproductive disorders and improving infertility. With advancements in standardizing protocol of SVF isolation and more clinical trials exploring its efficacy and safety, SVF should be promoted for more applications in practice.
