Scientometrics
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2024; 16(9): 832-841
Published online Sep 26, 2024. doi: 10.4252/wjsc.v16.i9.832
Stem cell transplantation in cerebrovascular accidents: A global bibliometric analysis (2000-2023)
Jad El Masri, Ahmad Afyouni, Maya Ghazi, Karim Hamideh, Israe Moubayed, Abdo Jurjus, Hanine Haidar, Ruzanna Petrosyan, Pascale Salameh, Hassan Hosseini
Jad El Masri, École Doctorale Sciences de la Vie et de la Santé, Université Paris-Est Créteil, Créteil 94010, France
Jad El Masri, Hassan Hosseini, INSERM U955-E01, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil 94000, France
Jad El Masri, Ahmad Afyouni, Maya Ghazi, Karim Hamideh, Israe Moubayed, Faculty of Medical Sciences, Lebanese University, Beirut 1533, Lebanon
Jad El Masri, Abdo Jurjus, Hanine Haidar, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut 1107, Lebanon
Maya Ghazi, Department of Neurology, Faculty of Medicine, Lebanese American University, Beirut 1102, Lebanon
Ruzanna Petrosyan, Department of Pathology, Faculty of Medicine, Lebanese American University, Beirut 1102, Lebanon
Pascale Salameh, Faculty of Pharmacy, Lebanese University, Beirut 1102, Lebanon
Pascale Salameh, Faculty of Medicine, Lebanese American University, Beirut 1102, Lebanon
Pascale Salameh, Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia 2408, Cyprus
Pascale Salameh, Institut National de Santé Publique d'Épidémiologie Clinique et de Toxicologie-Liban, Beirut 1103, Lebanon
Hassan Hosseini, Department of Neurology, Henri Mondor Hospital, AP-HP, Créteil 94000, France
Author contributions: Masri JE and Ghazi M conceptualized the study; Masri JE, Afyouni A, Hamideh K, and Hosseini H extracted and organized the data; Masri JE, Afyouni A, Hamideh K, and Jurjus A performed the data analyses; Masri JE, Afyouni A, Hamideh K, and Petrosyan R designed the methodology; Salameh P and Hosseini H supervised the study; Masri JE, Afyouni A, Ghazi M, Moubayed I, and Jurjus A wrote the original draft of the manuscript; Jurjus A, Haidar H, and Hosseini H reviewed and edited the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abdo Jurjus, PhD, Professor, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Bliss Street, Hamra, Beirut 1107, Lebanon. aj00@aub.edu.lb
Received: May 23, 2024
Revised: August 1, 2024
Accepted: September 18, 2024
Published online: September 26, 2024
Processing time: 123 Days and 12.8 Hours
Abstract
BACKGROUND

Cerebrovascular accident (CVA) is a major global contributor to death and disability. As part of its medical management, researchers have recognized the importance of promising neuroprotective strategies, where stem cell transplantation (SCT) is thought to confer advantages via trophic and neuroprotective effects.

AIM

To evaluate the current state of research on SCT in patients with CVA, assess key trends and highlight literature gaps.

METHODS

PubMed was screened for SCT in CVA-related articles in October 2023, for each country during the period between 2000 and 2023. Using the World Bank data, total population and gross domestic product were collected for comparison. VOSviewer_1.6.19 was used to create the VOS figure using the results of the same query. Graphs and tables were obtained using Microsoft Office Excel.

RESULTS

A total of 6923 studies were identified on SCT in CVA, making 0.03% of all published studies worldwide. Approximately, 68% were conducted in high-income countries, with a significant focus on mesenchymal stem cells. The journal “Stroke” featured the largest share of these articles, with mesenchymal SCT having the highest rate of inclusion, followed by hematopoietic SCT. Over time, there has been a noticeable shift from in vitro studies, which assess stem cell proliferation and neurogenesis, to in vivo studies aimed at evaluating efficacy and safety. Additionally, the number of reviews increased along this approach.

CONCLUSION

This bibliometric analysis provides a comprehensive guide for physicians and researchers in the field through an objective overview of research activity, and highlights both current trends and gaps. Having a potential therapeutic role in CVA, more research is needed in the future to focus on different aspects of SCT, aiming to reach a better treatment strategy and improve life quality in patients.

Keywords: Bibliometric analysis; PubMed; Stem cell transplantation; Cerebrovascular accidents; Stroke

Core Tip: This study evaluated the research landscape of stem cell transplantation in patients with cerebrovascular accident, highlighting trends and gaps. Analyzing publications from 2000 to 2023, we found that high-income countries lead stem cell transplantation research, predominantly using mesenchymal stem cells. The journal “Stroke” published the most articles. Recent research has shifted from in vitro studies to patient-oriented in vivo studies focusing on safety and efficacy. This trend indicates a maturing field moving towards clinical application. This study provides a comprehensive overview, guiding future research to optimize clinical outcomes for patients with cerebrovascular accident through stem cell transplantation.