Pei H, Zhang Y, Wang C, He BJ. Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis. World J Stem Cells 2024; 16(7): 739-741 [DOI: 10.4252/wjsc.v16.i7.739]
Corresponding Author of This Article
Bang-Jian He, Doctor, Chief Doctor, Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. hebangjian@163.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jul 26, 2024; 16(7): 739-741 Published online Jul 26, 2024. doi: 10.4252/wjsc.v16.i7.739
Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis
Hang Pei, Yi Zhang, Chao Wang, Bang-Jian He
Hang Pei, Yi Zhang, The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Chao Wang, Department of Orthopaedics, Anji County Hospital of Chinese Medicine, Anji 313300, Zhejiang Province, China
Bang-Jian He, Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Co-first authors: Hang Pei and Yi Zhang.
Author contributions: Pei H and Zhang Y contributed to this manuscript equally. Pei H was responsible for the conception and design of the editorial; Zhang Y and Wang C contributed to the drafting and revising of the manuscript; He BJ provided critical revisions and gave final approval of the version to be published. All authors read and approved the final manuscript.
Supported byNational Natural Science Foundation of China, No. 82074469.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bang-Jian He, Doctor, Chief Doctor, Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. hebangjian@163.com
Received: March 22, 2024 Revised: June 3, 2024 Accepted: June 27, 2024 Published online: July 26, 2024 Processing time: 125 Days and 3 Hours
Abstract
Recently, we read an article published by the Yang et al. The results of this study indicated that engineered exosomes loaded with microRNA-29a (miR-29a) alleviate knee inflammation and maintain extracellular matrix stability in Sprague Dawley rats. The study’s results provide useful information for treating knee osteoarthritis (KOA). This letter, shares our perspectives on treating KOA using engineered exosomes for miR-29a.
Core Tip: We recently reviewed a study that treated knee osteoarthritis using engineered exosomes. The authors found that this novel treatment approach is more effective than standard exosomes at symptom alleviation. This letter summarizes the advantages and limitations of this therapy and clarifies aspects of the original article.
