Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment: Facts and perspectives

doi:10.4252/wjsc.v16.i6.615

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Jun 26, 2024 (publication date) through Nov 4, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jun 26, 2024; 16(6): 615-618
Published online Jun 26, 2024. doi: 10.4252/wjsc.v16.i6.615

Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment: Facts and perspectives

Yu-Dong Zhao, Yong-Can Huang, Wei-Shi Li

Yu-Dong Zhao, Wei-Shi Li, Department of Orthopedic, Peking University Third Hospital, Beijing 100191, China

Yong-Can Huang, Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Orthopaedic Research Center, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China

Author contributions: Zhao YD wrote the manuscript; Li WS and Huang YC provided guidance and support.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Wei-Shi Li, MD, PhD, Professor, Surgeon, Department of Orthopedic, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China. puh3 Liweishi@163.com

Received: January 17, 2024
Revised: May 6, 2024
Accepted: June 4, 2024
Published online: June 26, 2024
Processing time: 160 Days and 2.1 Hours

Abstract

Mesenchymal stem/stromal cells are potential optimal cell sources for stem cell therapies, and pretreatment has proven to enhance cell vitality and function. In a recent publication, Li et al explored a new combination of pretreatment conditions. Here, we present an editorial to comment on their work and provide our view on mesenchymal stem/stromal cell precondition.

Keywords: Mesenchymal stem cell; Precondition; Hypoxia; Inflammation

Core Tip: Mesenchymal stem/stromal cells are important for stem cell therapies, and their vitality and function can be enhanced by hypoxia pretreatment. A novel combination of pretreatment was raised by Li et al. Here, we comment on their work and discuss related topics in this area.