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World J Stem Cells. Feb 26, 2024; 16(2): 126-136
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.126
Recent progress in hair follicle stem cell markers and their regulatory roles
Yi-Zhan Xing, Hai-Ying Guo, Fei Xiang, Yu-Hong Li
Yi-Zhan Xing, Hai-Ying Guo, Yu-Hong Li, Department of Cell Biology, Army Medical University, Chongqing 400038, China
Fei Xiang, Institute of Burn Research, Southwest Hospital, Army Medical University, Chongqing 400038, China
Author contributions: Xing YZ drafted the manuscript; Guo HY and Xiang F participated in the literature sorting; Guo HY prepared the table; Xiang F was involved in preparation of the figure; Li YH conceived and revised the manuscript; and all authors have read and approve the final manuscript.
Supported by National Natural Science Foundation of China, No. 82173446; and the Youth Training Program of the Army Medical University, No. 2018XQN01.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Hong Li, PhD, Associate Professor, Department of Cell Biology, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China. liyuhongtmmu@hotmail.com
Received: October 27, 2023
Peer-review started: October 27, 2023
First decision: December 5, 2023
Revised: December 19, 2023
Accepted: January 16, 2024
Article in press: January 16, 2024
Published online: February 26, 2024
Processing time: 122 Days and 2.4 Hours
Abstract

Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have been used to isolate, label, and trace HFSCs in recent years. Considering more detailed data from single-cell transcriptomics technology, we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

Keywords: Hair follicle stem cells, Bulge, Secondary hair germ, Marker, Single-cell RNA-sequencing

Core Tip: Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have been used to isolate, label, and trace HFSCs in recent years. Considering more detailed data from single-cell transcriptomics technology, we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.