Haider KH. Melatonin-based priming of stem cells to alleviate oxidative stress. World J Stem Cells 2024; 16(11): 985-989 [PMID: 39619873 DOI: 10.4252/wjsc.v16.i11.985]
Corresponding Author of This Article
Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, AlQaseem, Saudi Arabia. kh.haider@sr.edu.sa
Research Domain of This Article
Cell & Tissue Engineering
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Nov 26, 2024; 16(11): 985-989 Published online Nov 26, 2024. doi: 10.4252/wjsc.v16.i11.985
Melatonin-based priming of stem cells to alleviate oxidative stress
Khawaja Husnain Haider
Khawaja Husnain Haider, Department of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia
Author contributions: Haider KH conceptualized, wrote, reviewed, and edited the manuscript, and approved the publication of the final manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, AlQaseem, Saudi Arabia. kh.haider@sr.edu.sa
Received: September 17, 2024 Revised: September 28, 2024 Accepted: October 18, 2024 Published online: November 26, 2024 Processing time: 70 Days and 0.9 Hours
Abstract
Stem cell expansion in vitro and transplantation in the cytokine-rich proinflammatory milieu in the injured tissue generate immense oxidative stress that interferes with the cells’ survival, stemness, and repairability. Stem cell priming has gained popularity to overcome these issues. Given melatonin’s oxidative-scavenging properties, Gu et al have used periodontal ligament stem cells cultured under oxidative stress as an in vitro model to study the cytoprotective effects of melatonin. Our letter to the editor delves into melatonin-induced stem cell priming and the underlying molecular mechanism, focusing on the intriguing role of Yes-associated protein signaling in alleviating oxidative stress. We stress the importance of understanding the distinction between in vitro and in vivo oxidative stress conditions, a crucial aspect of stem cell research that invokes a sense of critical thinking in the readership. The study by Gu et al presents a novel approach to oxidative stress management, offering exciting possibilities for future research and applications.
Core Tip: Stem cell expansion in vitro is a routine procedure in stem cell-based therapy to achieve sufficient cells for transplantation. The potential of stem cell priming is crucial, offering a promising future for maintaining the cells’ survival, stemness, and repairability. The diverse priming strategies include physical, chemical, pharmacological, or genetic manipulation of the cells. Gu et al researched melatonin-induced priming of stem cells and the role of Yes-associated protein signaling in alleviating oxidative stress, reinforcing the priming strategy’s relevance and importance in cell-based therapy and instilling a sense of hope and optimism in the audience.
