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World J Stem Cells. Jun 26, 2021; 13(6): 521-541
Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.521
Recent trends in stem cell-based therapies and applications of artificial intelligence in regenerative medicine
Sayali Mukherjee, Garima Yadav, Rajnish Kumar
Sayali Mukherjee, Garima Yadav, Rajnish Kumar, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow 226028, Uttar Pradesh, India
Author contributions: Mukherjee S and Kumar R conceived of this manuscript; Yadav G and Mukherjee S performed the literature review and initial data collection; Mukherjee S, Yadav G and Kumar R wrote the manuscript; Kumar R and Mukherjee S edited and prepared the manuscript for submission.
Conflict-of-interest statement: Authors have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rajnish Kumar, BPharm, MTech, PhD, Assistant Professor, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Near Malhaur Railways Station, Lucknow 226028, Uttar Pradesh, India. rkumar2@lko.amity.edu
Received: February 16, 2021
Peer-review started: February 16, 2021
First decision: March 17, 2021
Revised: March 22, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: June 26, 2021
Processing time: 130 Days and 2.7 Hours
Abstract

Stem cells are undifferentiated cells that can self-renew and differentiate into diverse types of mature and functional cells while maintaining their original identity. This profound potential of stem cells has been thoroughly investigated for its significance in regenerative medicine and has laid the foundation for cell-based therapies. Regenerative medicine is rapidly progressing in healthcare with the prospect of repair and restoration of specific organs or tissue injuries or chronic disease conditions where the body’s regenerative process is not sufficient to heal. In this review, the recent advances in stem cell-based therapies in regenerative medicine are discussed, emphasizing mesenchymal stem cell-based therapies as these cells have been extensively studied for clinical use. Recent applications of artificial intelligence algorithms in stem cell-based therapies, their limitation, and future prospects are highlighted.

Keywords: Artificial intelligence; Machine learning; Mesenchymal stem cells; Regenerative medicine; Stem cells; Therapy

Core Tip: This article reviews some important types of stem cells in clinical treatment including embryonic stem cells, induced pluripotent stem cells, induced tissue-specific stem cells, and adult stem cells. Furthermore, the article focuses on the clinical treatment of mesenchymal stem cells and the application of artificial intelligence in induced pluripotent stem cells, their limitations, and future prospects.