Seiji Okada (MD, PhD) is a Professor of Joint Research Center for Human Retrovirus Infection & Graduate School of Medicine, and Director of the Radioisotope Center, Kumamoto University, Japan. He received his M.D. in 1985 and his Ph.D. degree in 1992 from Jichi Medical University, where he worked on the purification and characterization of murine hematopoietic stem cells. The c-kit+Sa-1+Lineage- (KSL) cells are still used as standard hematopoietic stem cell fraction (Blood, 1991). Then, he Prof. Takeshi Tokuhisa’s group in Chiba University as an Assistant Professor in 1996, and became an Associate Professor in 2000, where he focused on immune/hematopoietic cell differentiation and functional control by transcriptional factors (c-fos, bcl6). He was promoted to Professor at Kumamoto University in 2002. He started to establish highly immunodeficient mice as the recipients of human hematopoietic cells, and generated humanized mice and AIDS model mice. he is utilizing the immunodeficient mice to establish Patient-derived tumor xenograft (PDX) models of rare tumors. His current research interest is development of novel therapy for infection-related cancers such as AIDS-related lymphoma, adult T cell leukemia/lymphoma and liver-fluke-related cholangiocarcinoma. Publications: Academic English research papers with peer review 277. Review papers 10. Google Scholar's H-index: 53 (https://scholar.google.com/citations?user=p5lXj18AAAAJ). Awards: Japan Association for Development of Community Medicine, Research Award (1992), Japanese Society of Hematology, Young Investigator’s Award (1993), Mochida Memorial Foundation for Medical and Pharmaceutical Research, Research Award (1999), Chiba University Inohana Alumni Association, Academic Award (2000), Japan Leukemia Research Fund, Research Award (2010), Kumamoto University Education Activity Award (2017), The Honorary Doctorate Degree of Medicine, Khon Kaen University, Thailand (2018). Professional associations’ membership: American Society of Hematology, American Association of Immunologists, Japanese Society of Hematology (Councilor), Japanese Society of Immunology (Councilor), Japan Cytometry Society (Director), The Japanese Cancer Association (Councilor), Japanese Society for AIDS Research (Councilor). He is on the editorial board of 5 international journals. He is working on developing appropriate mouse models of human cancers and utilizing these models, so-called “Avatars”, for the development of novel therapies, especially immunotherapy. He has a background as an Internal physician, especially as a Hematologist. He has basic and advanced techniques in hematology and immunology. 1.Mice: He has several immunodeficient mice established in his Labo. BRJ (BALB/c Rag-1/Jak3 double deficient) mice and NOJ (NOD/Scid/Jak3 deficient) mice are optimized for human hematopoietic and tumor cell transplantation. Humanized mice, AIDS model mice, CDX (Human tumor cell line derived xenograft) and PDX (Patient-derived xenograft) models can be developed by BRJ & NOJ mice. 2.Flowcytometry and cell sorting: He has high-quality quality technique of multicolor analysis and single-cell sorting. 3.Establishment of human cancer cell lines: he established several hematopoietic and solid tumor cell lines. He has excellent teaching, communication, mentoring, management, and problem-solving skills based on his long-term experience as a physician and a university staff. He enjoys swimming every week. His style one is Butterfly. He is one of the directors of the Kumamoto Masters Swimming Association and has a license as a Sports doctor and Sports Instructor (Swimming) certificated by Japan Sports Association.