联合检测血清肿瘤标志物与M2-PK在结直肠癌筛查的价值

表1 各组血清中CEA、CA19-9和TuM2-PK表达水平比较［M(P25, P75)］

组别	n	CEA(ng/mL)	CA19-9(IU/mL)	TuM2-PK(U/mL)
结肠癌组	80	20.83(5.43-65.56)ab	22.83(7.02-87.65)ab	21.85(7.45-89.31)ab
良性疾病组	75	4.35(1.43-5.51)	14.24(8.15-19.42)	11.61(10.21-38.74)
健康对照组	90	3.06(0.14-5.17)	12.62(5.68-17.24)	9.08(12.21-29.62)
χ2		45.712	8.753	19.662
P		0.000	0.012	0.000

与良性疾病组比较,

^aP<0.05; 与健康对照组比较,

^bP<0.05. CEA: 癌胚抗原; CA19-9: 糖类抗原CA19-9; TuM2-PK: 丙酮酸激酶M2.

表2 血清CEA、CA19-9和TuM2-PK对结直肠癌的诊断效能

标志物	灵敏度(%)	特异度(%)	AUC(95%CI)	Cut-off值
CEA	71.25(57/80)	84.85(140/165)	0.72(0 .64-0 .82)	7.32 ng/mL
CA19-9	60.00(48/80)	90.30(149/165)	0.69(0 .56-0 .78)	38.26 IU/mL
TuM2-PK	73.75(59/80)	86.06(142/165)	0.85(0 .73-0 .90)	25.83 U/mL

CEA: 癌胚抗原; CA19-9: 糖类抗原CA19-9; TuM2-PK: 丙酮酸激酶M2.

表3 血清CA19-9、CEA和M2-PK联合诊断效率分析

标志物组合模式	灵敏度	特异度	准确度
CEA+CA19-9	76.25(61/80)a	84.85(140/165)	82.04(201/245)
CEA+TuM2-PK	78.75(63/80)a	84.85(140/165)	82.86(203/245)
CA19-9+TuM2-PK	73.75(59/80)a	86.06(142/165)	82.04(201/245)
CEA＋CA19-9+TuM2-PK	90.00(72/80)	84.85(140/165)	86.53(212/245)

与CEA+CA19-9+TuM2-PK联合检测比较,

^aP<0.05. CEA: 癌胚抗原; CA19-9: 糖类抗原CA19-9; TuM2-PK: 丙酮酸激酶M2.