基于16S rRNA序列分析肠道菌群失调与溃疡性结肠炎的相关性

表1 在溃疡性结肠炎组和对照组中相对丰度存在显著差异的属

属水平上物种分类	UC组		对照组		P值
	平均丰度	标准差	平均丰度	标准差
p__Actinobacteria; g__Collinsella(柯林斯氏菌)	0.011	0.031	0.111	0.182	0.038
p__Firmicutes; g__Clostridium(梭菌属)	0.287	0.303	2.323	2.449	0.009
p__Firmicutes; g__Coprococcus(粪球菌属)	0.104	0.161	1.133	1.633	0.046
p__Firmicutes; g__Lachnospira(毛螺菌属)	0.008	0.014	0.128	0.186	0.038
p__Firmicutes; g__Roseburia(罗斯氏菌属)	0.080	0.100	1.670	2.227	0.012
p__Proteobacteria; g__Flexispira(胃螺杆菌样细菌)1	0.062	0.053	0.018	0.014	0.038
p__Bacteroidetes; g__Alistipes(理研菌)	0	0	0.028	0.049	0.016
p__Firmicutes; g__Turicibacter(未定)	0.063	0.142	0.185	0.213	0.026
p__Firmicutes; g__Anaerostipes(丁酸弧菌)	0.0007	0.002	0.142	0.253	0.008
p__Firmicutes; g__Megasphaera(巨球型菌属)	0.0004	0.001	0.033	0.065	0.042

¹UC组别平均丰度高于对照组. UC: 溃疡性结肠炎.

表2 溃疡性结肠炎组和健康对照组在不同代谢通路中肠道微生物丰度差异

代谢通路	UC组		对照组		P值
	平均丰度	标准差	平均丰度	标准差
Signal Transduction
Phosphatidylinositol signaling system	0.1022	0.0155	0.0845	0.0182	0.019
Biosynthesis of Other Secondary
Metabolites;Isoflavonoid biosynthesis	8.97×10-6	8.03×10-6	9.75×10-7	1.39×10-7	0.003
Novobiocin biosynthesis1	0.1161	0.01	0.1277	0.0122	0.025
Lipid Metabolism
Linoleic acid metabolism	0.0851	0.0505	0.0518	0.0197	0.025
Primary bile acid biosynthesis	0.0416	0.0186	0.0257	0.012	0.019
Secondary bile acid biosynthesis	0.0414	0.0187	0.0255	0.012	0.018
Nucleotide Metabolism
Purine metabolism	2.2171	0.2176	2.0283	0.1561	0.018
Xenobiotics Biodegradation and Metabolism
Ethylbenzene degradation	0.0769	0.0643	0.0429	0.00795	0.018
Naphthalene degradation	0.1827	0.0823	0.13	0.0261	0.018
Nitrotoluene degradation1	0.0651	0.0346	0.1022	0.0198	0.025
Styrene degradation1	0.0155	0.0131	0.0329	0.0231	0.025

¹UC组别在该通路平均丰度比对照组高(P<0.05). UC: 溃疡性结肠炎.