Protein kinase C/ζ (PRKCZ) Gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes

Table 1 SPSS analysis results of genotyped SNPs in case and control group

SNP		Allele				Total	P value	Frequency of allele
		C	T	A	G
rs11740	Case	129	245			374	0.978	0.345
	Control	110	208			318		0.346
	Total	239	453			692
rs161825	Case			216	140	356	0.917	0.393
	Control			176	116	292		0.397
	Total			392	256	648
rs170629	Case	261	119			380	0.710	0.313
	Control	156	76			232		0.328
	Total	417	195			612
rs228648	Case			113	297	410	0.029	0.276
	Control			111	205	316		0.351
	Total			224	502	726
rs228669	Case	264	110			374	0.455	0.294
	Control	212	100			312		0.321
	Total	476	210			686
rs262669	Case	269	129			398	0.639	0.324
	Control	207	107			314		0.341
	Total	476	236			712
rs436045	Case	329	75			404	0.003	0.186
	Control	207	81			288		0.281
	Total	536	156			692
rs1801133	Case			224	156	380	0.607	0.411
	Control			133	101	234		0.432
	Total			357	257	614

Table 2 Statistical analysis of genotyped SNPs in PRKCZ

SNP name	Minor allele	Allele frequency (%)		P value
		Case	Control	χ2	T2
rs1878745	G	48.2	53.3	0.213	0.219
rs1467217	G	45.9	53.0	0.049	0.041
rs1401136	A	10.7	15.3	0.302	0.268
rs411021	T	17.9	27.3	0.005	0.007
rs436045	A	18.6	28.1	0.003	0.005
rs427811	G	17.9	28.0	0.009	0.013
rs385039	G	16.7	27.3	0.003	0.005
rs809912	A	16.7	27.3	0.003	0.005
rs262669	T	28.0	31.9	0.199	0.209
rs262662	C	28.4	35.9	0.029	0.030
rs381664	C	17.9	27.3	0.005	0.007
rs262650	A	20.4	27.3	0.022	0.030
rs262642	T	17.8	24.1	0.066	0.036

Table 3 Difference in frequencies of haplotypes formed by alleles of the 10 loci in case and control groups

Haplotypes	Frequency (%)
	Control	Case
CGTAGCTTGC	63.5	64.7
TAGGATCCAC	22.5	13.1
CGTAGTCTGC	7.8	6.2
TAGGATCCAT	4.5	2.9
CGTAGCCTGC	0.8	1.3
CGGAGTCTGC	0.4	0.7
CAGAGTCCAT	0.4	0
CGTAGCCTAC	0	2.9
CGTAGCTTGT	0	2.3
CGTAGTTTGC	0	2.3
CGTAGTCTAC	0	1.0
TAGGATTCGT	0	1.0
TAGAGTCCAC	0	0.3
CAGGATCCAT	0	0.3
CGGAGTTTGC	0	0.3
TAGGATTCGC	0	0.3
CGTAGTTCGC	0	0.3
TAGGATTTGT	0	0.3
TAGGACCCAT	0	0.3

Table 4 Difference in frequencies of haplotypes formed by alleles of the 5 loci in case and control groups

Haplotype	Frequency (%)		P value	OR
	Control	Case
CGTAG	72.1	81.0	0.007	1.652
TAGGA	27.0	17.3
CGGAG	0.4	1.0
CAGAG	0.4	0
TAGAT	0	0.3
CAGGA	0	0.3