Polymorphism in transmembrane region of MICA gene and cholelithiasis

Table 1 Phenotype frequencies of the polymorphism in transmembrane region of MICA gene in patients with cholelithiasis and controls

Phenotype	Patienta		Controla		Singleb		Particleb		Sandyb		Malec		Femalec
	n	%	n	%	n	%	n	%	n	%	n	%	n	%
A4	49	28.8	69	28.2	10	35.7	24	30.0	15	24.2	30	36.1	19	21.9
A5	85	50.0	133	54.3	15	53.6	43	53.8	27	43.6	42	50.6	43	49.4
A5.1	72	42.4	113	46.1	9	32.1	32	40.0	31	50.0	33	39.8	39	44.8
A6	23	13.5	30	12.2	4	14.3	10	12.5	9	14.5	9	10.8	14	16.1
A9	64	37.7	79	32.2	11	39.3	31	38.8	22	35.5	30	36.1	34	39.1
Total	170	100	245	100	28	100	80	100	62	100	83	100	87	100

^aP = 0.81,

^bP = 0.441,

^cP = 0.316.

Table 2 Allele frequencies of the polymorphism in transmembrane region of MICA gene in patients with cholelithiasis and controls

Allele	Patienta		Controla		Singleb		Particleb		Sandyb		Age at Dx ≤ 50		Age at Dx ≤ 30		Age at Dx ≤ 40d		Malec		Femalec
	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%
A4	53	15.6	74	15.1	11	19.6	26	16.3	16	12.9	21	13.8	3	15.0	5	8.1	34	20.5	19	10.9
A5	105	30.9	162	33.1	18	32.1	56	35.0	31	25.0	49	32.2	6	30.0	19	30.6	51	30.7	54	31.0
A5.1	85	25.0	135	27.6	11	19.6	35	21.9	39	31.5	39	25.7	5	25.0	18	29.0	38	22.9	47	27.0
A6	24	7.1	32	6.5	4	7.1	10	6.3	10	8.1	13	8.6	2	10.0	6	9.7	10	6.0	14	8.0
A9	73	21.5	87	17.8	12	21.4	33	20.6	28	22.6	30	19.7	4	20.0	14	22.6	33	19.9	40	23.0
Total	340	100	490	100	56	100	160	100	124	100	152	100	20	100	62	100	166	100	174	100

^aP = 0.71,

^bP = 0.541,

^cP = 0.415, ^dP = 0.501 (age ≤ 40 vs. control), Dx = Diagnosis.

Table 3 Genotype frequencies of the polymorphism in transmembrane region of MICA gene in patients with cholelithiasis and controls

Genotype	Patienta		Controlab		Singleb		Particleb		Sandyb		Age at Dx ≤ 50		Malec		Femalec
	n	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%
A4/A4	4	2.4	5	2.0	1	3.6	2	2.5	1	1.6	2	2.6	4	4.8	0	0
A4/A5	14	8.2	22	9.0	3	10.7	8	10.0	3	4.8	6	7.9	8	9.6	6	6.9
A4/A5.1	13	7.6	23	9.4	2	7.1	6	7.5	5	8.1	6	7.9	7	8.4	6	6.9
A4/A6	2	1.2	8	3.3	0	0	1	1.3	1	1.6	0	0	2	2.4	0	0
A4/A9	16	9.4	11	4.5	4	14.3	7	8.8	5	8.1	5	6.6	9	10.8	7	8.0
A5/A5	20	11.8	29	11.8	3	10.7	13	16.3	4	6.5	8	10.5	9	10.8	11	12.6
A5/A5.1	21	12.4	37	15.1	2	7.1	8	10.0	11	17.7	10	13.2	11	13.3	10	11.5
A5/A6	10	5.9	11	4.5	4	14.3	3	3.8	3	4.8	7	9.2	3	3.6	7	8.0
A5/A9	20	11.8	34	13.9	3	10.7	11	13.8	6	9.7	10	13.2	11	13.3	9	10.3
A5.1/A5.1	13	7.6	22	9.0	2	7.1	3	3.8	8	12.9	6	7.9	5	6.0	8	9.2
A5.1/A6	8	4.7	7	2.9	0	0	5	6.3	3	4.8	3	3.9	3	3.6	5	5.7
A5.1/A9	17	10.0	24	9.8	3	10.7	10	12.5	4	6.5	8	10.5	7	8.4	10	11.5
A6/A6	1	0.6	2	0.8	0	0	0	0	1	1.6	1	1.3	1	1.2	0	0
A6/A9	2	1.2	2	0.8	0	0	1	1.3	1	1.6	1	1.3	0	0	2	2.3
A9/A9	9	5.3	8	3.3	1	3.6	2	2.5	6	9.7	3	3.9	3	3.6	6	6.9
Total	170	100	245	100	28	100	80	100	62	100	76	100	83	100	87	100

^aP = 0.797,

^bP = 0.063 (control vs. stone types),

^cP = 0.337, Dx = Diagnosis.