Polymorphism in transmembrane region of MICA gene and cholelithiasis

doi:10.3748/wjg.v9.i7.1541

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 9, Issue 7

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2430)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

235

HTML

1926

Figures (1-1)

134

Tables (1-3)

135

Sum=2430

Jul 15, 2003 (publication date) through Apr 27, 2024

Times Cited of This Article

Times Cited (3)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Jul 15, 2003; 9(7): 1541-1544
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1541

Polymorphism in transmembrane region of MICA gene and cholelithiasis

Shou-Chuan Shih, Yann-Jinn Lee, Hsin-Fu Liu, Ching-Wen Dang, Shih-Chuan Chang, Shee-Chan Lin, Chin-Roa Kao

Shou-Chuan Shih, Division of Gastroenterology, Department of Medicine, Mackay Memorial Hospital; Mackay Junior School of Nursing, Taipei, Taiwan

Yann-Jinn Lee, Department of Pediatrics and Medical Research, Mackay Memorial Hospital; College of Medicine, Taipei Medical University, Taipei, Taiwan

Hsin-Fu Liu, Ching-Wen Dang, Shih-Chuan Chang, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan

Shee-Chan Lin, Chin-Roa Kao, Division of Gastroenterology, Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan

Author contributions: All authors contributed equally to the work.

Supported by MMH Grant 8844 from Mackay Memorial Hospital

Correspondence to: Dr. Yann-Jinn Lee, Departments of Pediatrics and Medical Research, Mackay Memorial Hospital, 92, Section 2, Chung-Shan North Road, Taipei, Taiwan. yannlee@ms2.mmh.org.tw

Telephone: +886-2-25433535 Fax: +886-2-25433642

Received: April 2, 2003
Revised: April 14, 2003
Accepted: April 24, 2003
Published online: July 15, 2003

Abstract

AIM: To study the significance of polymorphism of MHC class I chain-related gene A (MICA) gene in patients with cholelithiasis.

METHODS: Subjects included 170 unrelated adults (83 males) with cholelithiasis and 245 randomly selected unrelated adults (130 males) as controls. DNA was extracted from peripheral leukocytes and analyzed for polymorphism of 5 alleles (A4, A5, A5.1, A6 and A9) of the MICA gene.

RESULTS: There was no significant difference in phenotype, allele, and genotype frequencies of any of the 5 alleles between cholelithiasis patients and controls.

CONCLUSION: This study demonstrates that MICA alleles studied bear no relation to cholelithiasis.

Keywords: $[Keywords]