Genome-wide map of N6-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis

Table 1 Top 20 differently expressed N6-methyladenosine peaks compared with control group

	PeakStart	PeakEnd	circRNA	Regulation	Fold-change	P value
chr15	98658229	98658320	chr15:98656602-98658435-	Up	187.2	3.67392E-09
chr11	74929241	74929540	chr11:74928993-74990215+	Up	172.8	3.92116E-09
chr9	108248361	108248660	chr9:108207543-108263690-	Up	120.034482	3.70238E-08
chr2	153763381	153763760	chr2:153756037-153769786+	Up	106.330434	2.09239E-08
chr18	30281961	30282053	chr18:30276981-30282053+	Up	50.9545454	7.61781E-09
chr19	40346381	40346760	chr19:40314443-40373578-	Up	42.4	0.026929988
chr16	94641481	94641740	chr16:94611419-94694141+	Up	37.6772727	7.9549E-08
chr10	60144412	60144720	chr10:60144413-60144723-	Up	24.9	0.014047401
chr11	44652781	44652825	chr11:44651797-44652825+	Up	23.9	0.007108941
chr7	63895821	63896100	chr7:63891679-63938495-	Up	21.1	0.034908475
chr9	107852341	107852720	chr9:107847268-107860459-	Down	302.6	3.63198E-09
chr8	104143561	104143760	chr8:104143031-104143793+	Down	160.728571	1.15908E-08
chr1	150426881	150427260	chr1:150413021-150442180+	Down	52.095238	1.98141E-08
chr1	13312381	13312680	chr1:13298706-13325802-	Down	51.7	6.86061E-05
chr6	119970581	119970800	chr6:119951703-120038640-	Down	47.4	9.37286E-05
chr11	23271132	23271205	chr11:23261835-23271205+	Down	40.6	0.000442849
chr4	108499346	108499398	chr4:108486454-108508433+	Down	27.79	3.27262E-08
chr9	102619691	102619760	chr9:102618811-102619760-	Down	24.25	4.83147E-07
chr11	32296401	32296600	chr11:32283981-32297161+	Down	24.1	4.96449E-07
chr9	69414201	69414580	chr9:69408311-69432615+	Down	22.6	0.00943617

Table 2 The conservation analysis of the sequence between the selected circRNAs and human circRNAs

	Human circRNA
Mouse circRNA	Human circRNA	Hg19 location	Transcript	Parent gene	Sequence identity, %
chr15:98656602-98658435-	hsa_circ_0026065	chr12:49223538-49245957-	NM_004818	DDX23	88.75
chr11:74928993-74990215+	hsa_circ_0041387	chr17:2139785-2203958-	NM_001170957	SMG6	86.32
chr9:108207543-108263690-	hsa_circ_0124055	chr3:49514281-49548252+	NM_001177634	DAG1	85.36
chr2:153756037-153769786+	hsa_circ_0059811	chr20:31436477-31438211+	NM_012325	MAPRE1	84.18
chr19:40314443-40373578-	hsa_circ_0094611	chr10:97110965-97114724-	ENST00000371247.2	SORBS1	93.52
chr16:94611419-94694141+	hsa_circ_0115989	chr21:38792600-38888974+	ENST00000338785.3	DYRK1A	91.34
chr7:63891679-63938495-	hsa_circ_0034321	chr15:31619082-31670102+	NM_015995	KLF13	85.89
chr9:107847268-107860459-	hsa_circ_0065768	chr3:50000008-50114685+	NM_005777	RBM6	90.84
chr1:150413021-150442180+	hsa_circ_0111511	chr1:186294895-186325581-	NM_003292	TPR	87.91
chr1:13298706-13325802-	hsa_circ_0113369	chr1:42166586-42254891-	ENST00000247584.5	HIVEP3	91.30
chr6:119951703-120038640-	hsa_circ_0024963	chr12:939168-990955+	NM_001184985	WNK1	92.02
chr11:23261835-23271205+	hsa_circ_0120688	chr2:61749745-61764803-	ENST00000404992.2	XPO1	95.11
chr4:108486454-108508433+	hsa_circ_0012539	chr1:52927184-53018762-	NM_001009881	ZCCHC11	92.38
chr11:32283981-32297161+	hsa_circ_0118668	chr2:202780266-202790202-	None	None	91.48
chr9:69408311-69432615+	hsa_circ_0035568	chr15:60720627-60748993-	NM_024611	NARG2	87.08