Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application

Table 1 Long noncoding RNAs regulated by microRNAs in gastric cancer

lncRNA	Synonym	Pattern	miRNA	Function	Ref.
H19	ENSG00000130600	Up	miR-675	Proliferation and invasion	[27-29]
GAPLINC	ENSG00000266835	Up	miR-211-3p	Invasion and survival	[30]
ANRIL	ENSG00000240498	Up	miR-99a/449a	Tumor growth and invasion	[80]
BANCR	ENSG00000278910	Up	miR-532	Angiogenesis and metastasis	[81]
GAS5	ENSG00000234741	Down	miR-23a	Critical role in tumorigenesis	[82]
HOTAIR	ENSG00000228630	Up	miR-331-3p	Unknown	[83]
MALAT1	ENSG00000251562	Up	miR-23b-3p	Related to chemoresistance	[84]
MEG3	ENSG00000214548	Down	miR-21	Suppression of epithelial-mesenchymal transition	[85]
NEAT1	ENSG00000245532	Up	miR-506	Critical role in tumorigenesis	[86]
SNHG12	ENSG00000197989	Up	miR-199a/b-5p	Proliferation	[87]

lncRNA: Long noncoding RNA; miRNA: MicroRNA.

Table 2 Long noncoding RNAs as circulating biomarkers for gastric cancer

lncRNA	Synonym	Pattern	Tissue	Ref.
ZNFX1-AS1	ENSG00000177410	Up	Plasma	[67]
HULC	ENSG00000285219	Up	Plasma	[67]
H19	ENSG00000130600	Up	Plasma	[68]
UEGC1	-	Up	Exosomes	[70]
UEGC2	-	Up	Exosomes	[70]
PVT1	ENSG00000249859	Up	Gastric juice	[71]
ABHD11-AS1	ENSG00000225969	Up	Gastric juice	[72]
CCAT2	ENSG00000280997	Up	Plasma	[88]

lncRNA: Long noncoding RNA.