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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2020; 26(24): 3401-3412
Published online Jun 28, 2020. doi: 10.3748/wjg.v26.i24.3401
Published online Jun 28, 2020. doi: 10.3748/wjg.v26.i24.3401
Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application
Yue Gao, Jia-Yi Ren, Shang-Wei Ning, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Jun-Wei Wang, Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Mian Guo, Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Cheng-Wang Guo, Department of Gastroenterology and Gastrosurgery, Gansu Wuwei Tumor Hospital, Wuwei 733000, Gansu Province, China
Shan Yu, Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Author contributions: Gao Y, Wang JW, and Ren JY are all first authors and equally contributed to this work; Gao Y, Wang JW, and Ren JY contributed to the literature review and drafting of the manuscript and figures; Guo M, Guo CW, Ning SW, and Yu S contributed to the conception and design of the work, and critical revision and editing of the manuscript; all the authors approved the final version of the submitted manuscript.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shan Yu, MD, Doctor, Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150081, Heilongjiang Province, China. yushan@hrbmu.edu.cn
Received: December 29, 2019
Peer-review started: December 29, 2019
First decision: April 1, 2020
Revised: April 24, 2020
Accepted: May 20, 2020
Article in press: May 20, 2020
Published online: June 28, 2020
Peer-review started: December 29, 2019
First decision: April 1, 2020
Revised: April 24, 2020
Accepted: May 20, 2020
Article in press: May 20, 2020
Published online: June 28, 2020
Core Tip
Core tip: The noncoding genome exhibits an extensive landscape of cancer hallmarks. With the emergence of the promising effects of long noncoding RNAs (lncRNAs) in the treatment and diagnosis of cancer, advancements in the understanding of the molecular mechanisms of lncRNAs reveal a new era of therapeutic methods against gastric cancer and biomarkers. Although significant data imply the great translational application potential of lncRNAs in gastric cancer, these approaches still require further validation and a large cohort of patients to assess the long-term clinical outcomes.