Gao Y, Wang JW, Ren JY, Guo M, Guo CW, Ning SW, Yu S. Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application. World J Gastroenterol 2020; 26(24): 3401-3412 [PMID: 32655264 DOI: 10.3748/wjg.v26.i24.3401]
Corresponding Author of This Article
Shan Yu, MD, Doctor, Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150081, Heilongjiang Province, China. yushan@hrbmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yue Gao, Jia-Yi Ren, Shang-Wei Ning, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Jun-Wei Wang, Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Mian Guo, Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Cheng-Wang Guo, Department of Gastroenterology and Gastrosurgery, Gansu Wuwei Tumor Hospital, Wuwei 733000, Gansu Province, China
Shan Yu, Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Author contributions: Gao Y, Wang JW, and Ren JY are all first authors and equally contributed to this work; Gao Y, Wang JW, and Ren JY contributed to the literature review and drafting of the manuscript and figures; Guo M, Guo CW, Ning SW, and Yu S contributed to the conception and design of the work, and critical revision and editing of the manuscript; all the authors approved the final version of the submitted manuscript.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shan Yu, MD, Doctor, Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150081, Heilongjiang Province, China. yushan@hrbmu.edu.cn
Received: December 29, 2019 Peer-review started: December 29, 2019 First decision: April 1, 2020 Revised: April 24, 2020 Accepted: May 20, 2020 Article in press: May 20, 2020 Published online: June 28, 2020 Processing time: 182 Days and 1.1 Hours
Abstract
Long noncoding RNAs (lncRNAs) are important regulators of cell processes that are usually dysregulated in gastric cancer (GC). Based on their high specificity and ease of detection in tissues and body fluids, increasing attention has spurred the study of the roles of lncRNAs in GC patients. Thus, it is necessary to elucidate the molecular mechanisms and further explore the clinical applications of lncRNAs in GC. In this review, we summarize current knowledge to examine dysregulated lncRNAs in GC and their underlying molecular mechanisms and activities in GC, which involve microRNA sponging, mRNA stability, genetic variants, alternative splicing, transcription factor binding, and epigenetic modification. More significantly, the potential of lncRNAs as prognostic, circulating, and drug-resistant biomarkers for GC is also described. This review highlights the method of dissecting molecular mechanisms to explore the clinical application of lncRNAs in GC. Overall, this review offers assistance in using lncRNAs as novel candidates for molecular mechanisms and for the identification of revolutionary biomarkers for GC.
Core tip: The noncoding genome exhibits an extensive landscape of cancer hallmarks. With the emergence of the promising effects of long noncoding RNAs (lncRNAs) in the treatment and diagnosis of cancer, advancements in the understanding of the molecular mechanisms of lncRNAs reveal a new era of therapeutic methods against gastric cancer and biomarkers. Although significant data imply the great translational application potential of lncRNAs in gastric cancer, these approaches still require further validation and a large cohort of patients to assess the long-term clinical outcomes.
