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©The Author(s) 2019.
World J Gastroenterol. Oct 28, 2019; 25(40): 6116-6128
Published online Oct 28, 2019. doi: 10.3748/wjg.v25.i40.6116
Published online Oct 28, 2019. doi: 10.3748/wjg.v25.i40.6116
Table 1 Characteristics of patients enrolled in the two histological groups
IPAC | PPAC | P value | |
Total (n) | 17 | 23 | |
Age, yr (mean ± SD) | 58.1±8.4 | 57.8±7.8 | 0.929 |
Male/female, n | 12/5 | 14/9 | 0.524 |
CA19-9 positive (n) | 9 | 15 | 0.433 |
Size, mm (mean ± SD) | 15.5±5.1 | 17.4±5.7 | 0.273 |
Tumor differentiation | 4/10/3 | 2/13/8 | 0.288 |
Well/moderate/poor (n) | |||
Nodal involvement (n) | 4 | 5 | 0.893 |
Perineural invasion (n) | 1 | 9 | 0.016 |
Vessel involvement (n) | 2 | 3 | 0.904 |
Table 2 Interobserver agreement for volumetric histogram parameters
b = 800 s/mm2 | b = 1000 s/mm2 | |||
ADC parameter | ICC | 95%CI | ICC | 95%CI |
Mean | 0.992 | 0.984-0.996 | 0.994 | 0.989-0.997 |
Entropy | 0.959 | 0.922-0.978 | 0.952 | 0.910-0.975 |
Skewness | 0.742 | 0.153-0.864 | 0.781 | 0.585-0.884 |
Kurtosis | 0.399 | -0.136-0.682 | 0.486 | 0.029-0.728 |
5th | 0.954 | 0.912-0.976 | 0.978 | 0.959-0.989 |
10th | 0.974 | 0.950-0.986 | 0.975 | 0.952-0.987 |
25th | 0.988 | 0.976-0.993 | 0.991 | 0.983-0.995 |
50th | 0.989 | 0.978-0.994 | 0.996 | 0.992-0.998 |
75th | 0.984 | 0.969-0.991 | 0.992 | 0.985-0.996 |
90th | 0.973 | 0.948-0.986 | 0.981 | 0.965-0.990 |
95th | 0.975 | 0.950-0.987 | 0.977 | 0.966-0.988 |
ADCmin | 0.981 | 0.965-0.990 | 0.984 | 0.970-0.992 |
ADCmax | 0.951 | 0.908-0.974 | 0.948 | 0.901-0.972 |
Table 3 Results of apparent diffusion coefficient histogram analysis between intestinal-type and pancreatobiliary-type periampullary adenocarcinoma
b = 800 s/mm2 | b = 1000 s/mm2 | |||||
IPAC | PPAC | P | IPAC | PPAC | P | |
Mean | 1.38±0.33 | 1.24±0.24 | 0.146 | 1.33±0.25 | 1.11±0.25 | 0.009 |
5th | 1.01 ± 0.23 | 0.93 ± 0.25 | 0.312 | 0.99 ± 0.22 | 0.85 ± 0.27 | 0.094 |
10th | 1.07 ± 0.24 | 0.99 ± 0.24 | 0.259 | 1.06 ± 0.23 | 0.89 ± 0.26 | 0.040 |
25th | 1.22 ± 0.31 | 1.09 ± 0.24 | 0.146 | 1.16 ± 0.24 | 0.99 ± 0.25 | 0.030 |
50th | 1.37 ± 0.33 | 1.23 ± 0.24 | 0.123 | 1.31 ± 0.25 | 1.09 ± 0.25 | 0.011 |
75th | 1.51 ± 0.37 | 1.36 ± 0.25 | 0.159 | 1.47 ± 0.28 | 1.21 ± 0.25 | 0.004 |
90th | 1.66 ± 0.40 | 1.49 ± 0.28 | 0.136 | 1.61 ± 0.32 | 1.32 ± 0.26 | 0.004 |
95th | 1.76 ± 0.42 | 1.56 ± 0.30 | 0.136 | 1.68 ± 0.33 | 1.40 ± 0.28 | 0.010 |
ADCmin | 0.87±0.32 | 0.82±0.30 | 0.583 | 0.89±0.24 | 0.79±0.27 | 0.227 |
ADCmax | 1.93±0.51 | 1.73±0.37 | 0.178 | 1.84±0.32 | 1.54±0.36 | 0.008 |
Entropy | 3.56±0.55 | 3.55±0.56 | 0.926 | 3.46±0.56 | 3.40±0.60 | 0.748 |
Table 4 Diagnostic performance of the volumetric histogram parameters at b1000
ADC parameter | AUC (95%CI) | Cut-off (10-3 mm2/s) | Sensitivity (%) | Specificity (%) |
Mean | 0.762(0.601-0.882) | 1.40 | 91 | 52 |
5th | 0.703 (0.538-0.837) | 1.09 | 78 | 58 |
10th | 0.723 (0.558-0.825) | 0.90 | 57 | 82 |
25th | 0.742 (0.579-0.867) | 1.34 | 83 | 59 |
50th | 0.781 (0.623 0.896) | 1.50 | 91 | 59 |
75th | 0.774 (0.613-0.892) | 1.44 | 78 | 69 |
90th | 0.750 (0.581-0.877) | 1.52 | 82 | 67 |
ADCmax | 0.747(0.585-0.871) | 1.63 | 70 | 82 |
- Citation: Lu JY, Yu H, Zou XL, Li Z, Hu XM, Shen YQ, Hu DY. Apparent diffusion coefficient-based histogram analysis differentiates histological subtypes of periampullary adenocarcinoma. World J Gastroenterol 2019; 25(40): 6116-6128
- URL: https://www.wjgnet.com/1007-9327/full/v25/i40/6116.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i40.6116