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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2019; 25(40): 6116-6128
Published online Oct 28, 2019. doi: 10.3748/wjg.v25.i40.6116
Published online Oct 28, 2019. doi: 10.3748/wjg.v25.i40.6116
Apparent diffusion coefficient-based histogram analysis differentiates histological subtypes of periampullary adenocarcinoma
Jing-Yu Lu, Hao Yu, Xian-Lun Zou, Zhen Li, Xue-Mei Hu, Ya-Qi Shen, Dao-Yu Hu, Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Jing-Yu Lu, Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Author contributions: All authors contributed to the design of the study; Lu JY and Shen YQ wrote the manuscript; Yu H and Hu XM contributed to the measurement; Lu JY and Zou XL contributed to data acquisition and prepared the tables and figures; Li Z, Shen YQ, and Hu DY revised the manuscript; all authors reviewed the manuscript and approved the final vision to be submitted.
Supported by the National Natural Science Foundation of China , No. 81701657, No. 81571642, No. 81801695, and No. 81771801 ; the Fundamental Research Funds for the Central Universities , No. 2017KFYXJJ126 .
Institutional review board statement: This study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Informed consent statement: All patients agreed to MR examination and treatment with written consent. Due to the retrospective nature of the present study, the additional informed consent was waived.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ya-Qi Shen, MD, PhD, Doctor, Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. yqshen@hust.edu.cn
Telephone: +86-27-83662640 Fax: +86-27-83662640
Received: July 23, 2019
Peer-review started: July 23, 2019
First decision: August 27, 2019
Revised: September 17, 2019
Accepted: September 27, 2019
Article in press: September 28, 2019
Published online: October 28, 2019
Peer-review started: July 23, 2019
First decision: August 27, 2019
Revised: September 17, 2019
Accepted: September 27, 2019
Article in press: September 28, 2019
Published online: October 28, 2019
Core Tip
Core tip: Two subtypes of periampullary adenocarcinoma were investigated in the present study: one is intestinal-type periampullary adenocarcinoma (IPAC), and the other is pancreatobiliary-type periampullary adenocarcinoma (PPAC). The aim of the present study was to distinguish these two subtypes by volumetric apparent diffusion coefficient (ADC) histogram analysis. Forty pathologically confirmed patients were enrolled. The mean, maximum, and various percentiles of ADC values derived from b1000 were lower in the PPAC group than in the IPAC group with statistical significance. The 75th percentile of ADC values achieved the highest area under the curve.