Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors — 8 cases: A case report

Table 1 Summary of the clinical features of eight patients with intra-abdominal desmoid tumor after gastrointestinal stromal tumor

	Age in yr/sex	Location of GIST	Metabolic activity with SUVmax in GIST	Primary surgery	Genotype of GIST	Imatinib for GIST	Interval1 (mo)	Metabolic activity with SUVmax in DT	Sites of DT	Surgery for DT	Size (cm) of DT2	Patient status
1	59/F	Stomach	-	W/R	KIT exon 11	No	31.5	3.5	Peritoneum, celiac area	Open biopsy	3.7	F/U loss
2	63/F	Sigmoid	4.3	LAR	KIT exon 9	Yes	13.9	2.2	Peritoneum, pelvic area	SB R and A, mass excision	2	Recurrence of GIST
3	58/M	Stomach	-	W/R	-	Yes	23.7	No	Peritoneum, LUQ area	Lap. W/R of stomach, mass excision	1.7	NED
4	50/M	Stomach	-	TG	-	Yes	20.3	-	Peritoneum, pelvic area	SB R and A, mass excision	6.7	NED
5	67/M	Duodenum	6.33	PPPD	-	Yes	13.5	No	Peritoneum, pelvic area	Excision of SB mesentery	2.2	Recurrence of GIST
6	56/M	Jejunum	-	Seg. resection	-	Yes	10.9	3.2	Peritoneum, pelvic area	SB R and A	3	Recurrence of DT
7	40/F	SB with peritoneum, liver, ovary	-	SB R and A	KIT exon 11	Yes	28.5	2.7	Peritoneum, pelvic area	SB R and A	3.3	Stable GIST with imatinib
8	72/M	Stomach, recurrent SB with peritoneum	4.9	Lap. W/R	-	Yes	84.6	-	Peritoneum, adrenal area	Mass excision	1.3	Stable GIST with imatinib

¹Interval, from the date of primary resection of gastrointestinal stromal tumor (GIST) to the date of diagnosis of desmoid tumor (DT).

²Size of DT was based on the pathological specimen.

³The maximum standardized uptake values of recurrent GIST.

GIST: Gastrointestinal stromal tumor; DT: Desmoid tumor; W/R: Wedge resection; F/U: Follow-up; EUS: Endoscopic ultrasound; LAR: Lower anterior resection; SB R and A: Small bowel resection and anastomosis; LUQ: Left upper quadrant; TG: Total gastrectomy; PPPD: Pylorus preserving pancreaticoduodenectomy; Seg: Segmental.

Table 2 Comparison between previous cases in the literatures and patients included in the present case series

	Previous cases1 (n = 27)	Present cases (n = 8)
Sex (Male : Female)	19:7 (one patient; unknown)	5:3
Age (yr) (median, range)	58 (34-74)	58.5 (40-72)
Primary GIST
Stomach	20	4
Small bowel	11	3
Peritoneum	2	0
Colon and rectum	0	1
Disease status following the occurrence of a new single lesion	62	8
Localized GIST	5	6
Metastatic GIST	1	2
Imatinib for GIST following the occurrence of a new single lesion	19	7
Interval time from surgical resection of GIST to the diagnosis of DT (yr)	2.5 (0.5-15.9)	1.8 (0.9-7.1)
Sites of DT
Stomach	1	-
Small bowel	5	-
Colon	1	-
Peritoneum/Mesentery	15	8
Others (liver and spleen)	2	-
Extra-abdominal organ3	3	-
Size of DT (cm) (median, range)	6.5 (1.6–17)4	2.6 (1.3-6.7)

¹Previous case reports[5-9] and cases with desmoid tumor after gastrointestinal stromal tumor [3].

²Available previous data (n = 6).

³Abdominal wall (n = 2) and thigh (n = 1).

⁴Available previous data (n = 6).

GIST: Gastrointestinal stromal tumor; DT: Desmoid tumor.