Kim JH, Ryu MH, Park YS, Kim HJ, Park H, Kang YK. Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors — 8 cases: A case report. World J Gastroenterol 2019; 25(16): 2010-2018 [PMID: 31086468 DOI: 10.3748/wjg.v25.i16.2010]
Corresponding Author of This Article
Yoon-Koo Kang, MD, PhD, Doctor, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. ykkang@amc.seoul.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 28, 2019; 25(16): 2010-2018 Published online Apr 28, 2019. doi: 10.3748/wjg.v25.i16.2010
Intra-abdominal desmoid tumors mimicking gastrointestinal stromal tumors — 8 cases: A case report
Jwa Hoon Kim, Min-Hee Ryu, Young Soo Park, Hyun Jin Kim, Hyojung Park, Yoon-Koo Kang
Jwa Hoon Kim, Min-Hee Ryu, Yoon-Koo Kang, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea
Young Soo Park, Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea
Hyun Jin Kim, Hyojung Park, Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea
Author contributions: Kang YK designed the research; Kim JH and Ryu MH performed the research; Park YS contributed to analysis of the pathology data; Kim HJ and Park H contributed to analysis of the radiology data; Kim JH wrote the paper.
Informed consent statement: All procedures performed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and the Helsinki Declaration of 1964 and later versions. Informed consent or a substitute of consent was obtained from all patients prior to inclusion in the study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yoon-Koo Kang, MD, PhD, Doctor, Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. ykkang@amc.seoul.kr
Telephone: +82-230103230 Fax: +82-2-30108772
Received: December 31, 2018 Peer-review started: January 3, 2019 First decision: February 13, 2019 Revised: February 22, 2019 Accepted: March 1, 2019 Article in press: March 2, 2019 Published online: April 28, 2019 Processing time: 115 Days and 0.8 Hours
Abstract
BACKGROUND
Intra-abdominal desmoid tumors (DTs) can mimic recurrence or progression of gastrointestinal stromal tumors (GISTs). Differential diagnosis is important to avoid unnecessary or inappropriate treatment.
CASE SUMMARY
All 8 patients experienced surgical resection of GIST, and median time to diagnosis of DT was 1.8 years after surgical resection. All sites of DT were in the peritoneum around the surgical sites of GIST. The following clinical suspicion coupled with radiological findings contributed to the suspicion of intra-abdominal DTs: (1) Occurrence of a new single lesion in the peritoneum around the surgical sites of GIST; (2) uncontrolled lesion with imatinib while other lesions being controlled with imatinib; (3) well-defined ovoid shaped lesion with delayed or mild enhancement and absence of necrosis, hemorrhage, and cystic change on computed tomography; and (4) a lesion showing mild or no hypermetabolic activity on 18fluorodeoxyglucose-positron emission tomography, contrary to initially hyperactive lesion of GIST. All DTs were surgically removed except for one unresectable DT and only one DT recurred at another site of peritoneum, which was also surgically removed.
CONCLUSION
Intra-abdominal DT should be a differential diagnosis for a new single lesion in patients with GIST.
Core tip: Intra-abdominal desmoid tumor should be considered as a differential diagnosis for a new single lesion in patients with gastrointestinal stromal tumor (GIST): (1) Occurrence of a new single lesion in the peritoneum around the surgical sites of GIST; (2) uncontrolled lesion with imatinib while other lesions being controlled with imatinib; (3) well-defined ovoid shaped lesion with delayed or mild enhancement and absence of necrosis, hemorrhage, and cystic change on computed tomography; and (4) a lesion showing mild or no hypermetabolic activity on 18fluorodeoxyglucose-positron emission tomography, contrary to initially hyperactive lesion of GIST.
