Retrospective Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Aug 21, 2017; 23(31): 5764-5772
Published online Aug 21, 2017. doi: 10.3748/wjg.v23.i31.5764
Table 1 Clinicopathological characteristics of the patients
Characteristicn
Age
Median (range)70 (34-85)
Sex
Male66
Female70
Location
Head80
Body-tail56
Tumor size in cm
Median (range)3 (1-18)
Surgery
Pancreaticoduodenectomy76
Distal pancreatectomy54
Total pancreatectomy6
Histological differentiation
G120
G289
G317
G410
AJCC staging system
IA5
IB15
IIA46
IIB56
III3
IV11
Lymph node
N070
N166
Adjuvant therapy
Yes96
No40
Resection margin status
R086
R135
R215
Table 2 Association between doublecortin and CaM kinase-like-1 expression and clinicopathological factors in resected pancreatic ductal adenocarcinoma n (%)
CharacteristicDCLK-1, n = 136
P value
Positive, n = 66Negative, n = 70
Tumor size in cm0.2962
< 211 (16.7)17 (24.3)
≥ 255 (83.3)53 (75.7)
Histological grade0.0290
G15 (7.6)15 (21.4)
G2-461 (92.4)55 (78.6)
T category0.4326
T1/T214 (21.2)19 (27.1)
T3/T452 (78.8)51 (72.9)
N category1.00
N034 (51.5)37 (52.9)
N132 (48.5)33 (47.1)
Serum CA19-9 level0.0060
Normal14 (21.2)31 (44.3)
Elevated52 (78.8)39 (55.7)
Serum SPan-1 level
Normal23 (34.8)34 (48.6)0.1198
Elevated43 (65.2)36 (51.4)
Residual tumor0.2148
R038 (57.6)48 (68.6)
R1/228 (42.4)22 (31.4)
Snail0.1237
Positive41 (62.1)34 (48.6)
Negative25 (37.9)36 (51.4)
E-cadherin0.1151
Positive31 (47.0)23 (32.9)
Negative35 (53.0)47 (67.1)
N-cadherin0.5967
Positive23 (34.8)28 (40.0)
Negative43 (65.2)42 (60.0)
Vimentin0.5232
Positive6 (9.1)4 (5.7)
Negative60 (90.9)66 (94.3)
CD240.3758
Positive27 (40.9)23 (32.9)
Negative39 (59.1)47 (67.1)
CD441.00
Positive49 (74.2)52 (74.3)
Negative17 (25.8)18 (25.7)
EpCAM0.0235
Positive46 (69.7)35 (50.0)
Negative20 (30.3)35 (50.0)
CD1330.8301
Positive12 (18.2)14 (20.0)
Negative54 (81.8)56 (80.0)
CD24+CD44+EpCAM+0.0139
Positive18 (27.3)7 (10.0)
Negative48 (72.7)63 (90.0)
Table 3 Univariate and multivariate survival analyses in resected pancreatic ductal adenocarcinoma
VariableComparisonUnivariate analysis
Multivariate analysis
nMST in moP valueHazard ratio95%CIP value
Tumor size in cm< 22836.60.0735
≥ 210823.8
Histological gradeG120Not reached0.00911.3620.844-2.3180.2130
G2-411623.8
T categoryT1/T23330.30.7279
T3/T410328.27
N categoryN07135.40.0505
N16521.2
Serum CA19-9Normal4531.370.2057
Elevated9124.43
Serum SPan-1Normal5736.60.00341.2860.905-1.8400.1608
Elevated7921.2
Adjuvant therapyNo3023.30.21
Yes9630.3
Resection margin statusR08636.6< 0.00012.0191.380-2.9330.0004
R1/25017.9
DCLK1Negative7050.1< 0.00011.8481.2854-2.6610.0009
Positive6621.0
SnailNegative6130.30.2377
Positive7526.57
E-cadherinNegative8226.570.5448
Positive5430.3
N-cadherinNegative8526.570.4568
Positive5136.03
VimentinNegative12630.070.0659
Positive1017.9
CD24Negative8624.430.6359
Positive5030.3
CD44Negative3545.10.02451.2670.855-1.9190.2414
Positive10124.43
CD133Negative11023.370.1485
Positive2636.6
EpCAMNegative5523.370.6580
Positive8130.07