Accuracy of endoscopic ultrasound-guided tissue acquisition in the evaluation of lymph nodes enlargement in the absence of on-site pathologist

Table 1 Demographics and lymph node characteristics by location n (%)

Characteristics	Total (n = 168)	Abdominal (n = 78)	Mediastinal (n = 90)	P value
Size (mm), mean ± SD	20.3 ± 9.9	19.3 ± 9.0	21.4 ± 18.4	0.280
Histology needle	105 (61.3)	48 (61.5)	57 (61.1)	0.955
19-G	17 (10.1)	5 (6.4)	12 (13.3)
20-G	7 (4.2)	3 (3.9)	4 (4.4)
22-G	48 (28.6)	23 (29.5)	25 (27.8)
25-G	33 (19.6)	17 (21.8)	16 (17.8)
Cytology needle	63 (38.7)	30 (38.5)	33 (38.9)	0.955
19-G	4 (2.4)	-	4 (5.6)
22-G	30 (17.9)	14 (18.0)	16 (17.8)
25-G	29 (17.3)	16 (20.5)	13 (14.4)
No. of passes (median, range)	214	99 (11, 4)	115 (1, 1-3)

Table 2 Endoscopic ultrasound fine-needle aspiration/fine-needle biopsy diagnoses and final diagnoses in 168 lymph nodes n (%)

	EUS FNA/FNB diagnoses	Final diagnoses
Metastasis
Carcinoma	51 (30.3)	62 (36.9)
Neuroendocrine	2 (1.2)	2 (1.2)
Melanoma	1 (0.6)	1 (0.6)
Benign/reactive
Granulomatous	8 (4.8)	21 (12.5)
Unspecific reactive	100 (59.5)	66 (39.3)
Lymphoma	6 (3.6)	16 (9.5)

EUS: Endoscopic ultrasound; FNA: Fine-needle aspiration; FNB: Fine-needle biopsy.

Table 3 Accuracy of endoscopic ultrasound fine-needle aspiration/fine-needle biopsy for diagnosis of malignancy

Overall (n = 168)	Estimate (%)	95%CI
Sensitivity	74.1%	63.6-82.4
Specificity	100%	95.8-100
Positive predictive value	100%	94.0-100
Negative predictive value	80.6%	72.1-86.9
Accuracy	87.5%	81.7-91.7

Table 4 Analysis of factors associated with the diagnostic accuracy of endoscopic ultrasound fine-needle aspiration/fine-needle biopsy

Variable	OR (95%CI)	P value	OR (95%CI)	P value
Mediastinal location	1.05 (0.42-2.64)	0.907	0.93 (0.30-2.92)	0.900
Histology needle	1.02 (0.40-2.64)	0.952	1.01 (0.31-3.31)	0.993
No. of passes	0.58 (0.27-1.24)	0.161	1.54 (0.41-5.80)	0.522
Size	0.98 (0.93-1.03)	0.383	0.98 (0.93-1.03)	0.411