Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1 vs University of Wisconsin appraisal

Table 1 ALT and AST (Liver injury) and GLDH (mitochondrial damage) in steatotic liver grafts preserved in University of Wisconsin and Institut Georges Lopez-1 solutions and then subjected to two hours of normothermic reperfusion

Liver injury	Cont2	UW	IGL-1
ALT, U/L	26.76 ± 4.095	172.1 ± 10.81a	92.99 ± 8.64ac
AST, U/L	24.92 ± 2.42	280.93 ± 14.14a	202.24 ± 24.71ac
GLDH, U/L	26.13 ± 6.83	425.22 ± 156.92a	143 ± 31.16ac

^aP < 0.05 vs Cont,

^cP < 0.05 vs UW. UW: University of Wisconsin; IGL-1: Institut Georges Lopez-1.

Table 2 TNFα, IL-1 and IL-10 levels (inflammation) in steatotic liver grafts preserved in University of Wisconsin and Institut Georges Lopez-1 solutions and then subjected to two hours of normothermic reperfusion

Inflammation	Cont2	UW	IGL-1
TNFα (pg/mL)	26.17 ± 5.85	1285.89 ± 231.32a	1005.83 ± 101.94ac
IL-1β (pg/mL)	4.29 ± 1.66	89.01 ± 10.53a	84.69 ± 7.79a
IL-10 (pg/mL)	134.89 ± 14.84	109.33 ± 17.3a	192.13 ± 7.73ac

^aP < 0.05 vs Cont,

^cP < 0.05 vs UW. UW: University of Wisconsin; IGL-1: Institut Georges Lopez-1.