Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats

doi:10.3748/wjg.v22.i8.2558

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Feb 28, 2016 (publication date) through Dec 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2016; 22(8): 2558-2565
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2558

Table 1 Herbal prescription of improved prescription of Taohechengqi-tang

Chinese name	Latin name	Origin	Amount in preparation (g)
Chi-shao	Radix paeoniae rubra	Sichuan	100
Tao-ren	Semen persicae	Hebei	50
Hong-hua	Flos carthami	Sichuan	50
Shui-zhi	Hirudo	Sichuan	15
Quan-xie	Scorpio	Henan	10
Mang-xiao	Natrii sulfas	Sichuan	10
Da-huang	Radix et rhizoma rhei palmati	Sichuan	30

Table 2 Biochemistry and histopathology

Group	n	ALT (U/L)	AST (U/L)	TBiL (μmol/L)	ALB (g/L)	CHE (U/L)	PT (s)	Histopathological scores
Control	10	35.15 ± 6.01	151.61 ± 20.87	1.55 ± 0.43	35.25 ± 4.19	557.40 ± 43.23	13.60 ± 1.73	0
Model	20	441.10 ± 60.36^a	887.80 ± 128.47^a	38.04 ± 6.84^a	23.67 ± 3.21^a	343.92 ± 68.93^a	31.80 ± 5.02^a	3.69 ± 0.38^a
SNMC	20	267.18 ± 41.45^b	380.49 ± 55.38^b	24.37 ± 4.03^b	26.65 ± 4.50	378.50 ± 83.53	29.93 ± 3.83	2.78 ± 0.31^b
IPTT	20	127.45 ± 25.33^b^c	264.04 ± 63.432^b^c	19.37 ± 3.26^b^c	30.22 ± 4.30^b^c	488.61 ± 76.41^b^c	23.78 ± 4.34^b^c	2.06 ± 0.40^b^c

^aP < 0.05 vs control group;

^bP < 0.05 vs group; and

^cP < 0.05 vs SNMC group. Control group: Negative control group; Model group: Injected with D-GalN; SNMC group: Injected with D-GalN and treated with SNMC; IPTT group: Injected with D-GalN and treated with modified Taohechengqi-tang.

Table 3 mRNA expression and proliferating cell nuclear antigen immunohistochemistry

Group	n	HMGB1	TLR4	NF-κB	Caspase-3	PCNA (%)
Control	10	0.01 ± 0.01	0.04 ± 0.02	0.49 ± 0.25	1.36 ± 0.26	7.48 ± 0.90
Model	20	0.25 ± 0.04^a	0.41 ± 0.22^a	2.68 ± 1.35^a	3.41 ± 0.85^a	17.55 ± 2.40
SNMC	20	0.11 ± 0.04^b	0.22 ± 0.08^b	1.78 ± 0.64^b	2.57 ± 1.04^b	25.57 ± 2.94^b
IPTT	20	0.06 ± 0.03^b^c	0.07 ± 0.02^b^c	0.74 ± 0.41^b^c	1.61 ± 0.45^b^c	36.34 ± 4.91^b^c

^aP < 0.05 vs control group;

^bP < 0.05 vs model group; and

^cP < 0.05 vs SNMC group. HMGB: High mobility group box; TLR: Toll-like receptor; NF: Nuclear factor; PCNA: Proliferating cell nuclear antigen; Control group: Negative control group; Model group: Injected with D-GalN; SNMC group: Injected with D-GalN and treated with SNMC.

Citation: Zhang Y, Luo JX, Hu XY, Yang F, Zhong S, Lin W. Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats. World J Gastroenterol 2016; 22(8): 2558-2565
URL: https://www.wjgnet.com/1007-9327/full/v22/i8/2558.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i8.2558