Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2016; 22(8): 2558-2565
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2558
Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats
Yang Zhang, Jian-Xing Luo, Xiao-Yu Hu, Fang Yang, Sen Zhong, Wu Lin
Yang Zhang, Jian-Xing Luo, Xiao-Yu Hu, Sen Zhong, Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Fang Yang, Department of Neurology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Wu Lin, Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Author contributions: Zhang Y and Luo JX contributed equally to this work; Hu XY and Zhong S designed the study; Hu XY, Zhang Y, Luo JX, Yang F and Lin W performed study; Zhang Y and Yang F analyzed data; and Zhang Y wrote the paper.
Supported by National Key Technology R and D Program, No. 2008ZX10005 and No. 2009ZX10005.
Institutional review board statement: This study was approved by the Institutional Review Board of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Institutional animal care and use committee statement: All animal experiments were carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by the Institutional Animal Care and Use Committee of Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: There are no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Xiao-Yu Hu, Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Street, Chengdu 610072, Sichuan Province, China. xiaoyuhu@aliyun.com
Telephone: +86-28-87766041 Fax: +86-28-87732407
Received: July 8, 2015
Peer-review started: July 9, 2015
First decision: September 29, 2015
Revised: October 13, 2015
Accepted: November 24, 2015
Article in press: November 24, 2015
Published online: February 28, 2016
Processing time: 232 Days and 0.5 Hours
Core Tip

Core tip: Acute liver failure (ALF) is a life-threatening condition. Our prospective cohort study demonstrated that high doses of herbs for clearing heat and resolving stasis have a protective effect on LF. However, the curative mechanism is unclear. Our evidence showed that improved prescription of Taohechengqi-tang attenuated the inflammatory reaction of ALF in rats via inhibition of high mobility group box 1 production, which may contribute to recovery of limited liver regeneration. We provide evidence for the clinical application of Chinese herbs for clearing heat and resolving stasis.